Guidance

Immunoglobulin: when to use

PHE's immunoglobulin handbook, providing guidance on administering immunoglobulin to prevent serious disease.

Documents

Rabies and Immunoglobulin Service (RIgS)

Hepatitis A immunoglobulin: June 2017

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General product information and how to administer immunoglobulin: July 2014

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Guidance on the use of Diphtheria anti-toxin (DAT): August 2018

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Hepatitis B immunoglobulin: October 2008

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Babies of hepatitis B infected mothers: August 2008

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Mumps and immunoglobulin: October 2008

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Polio immunoglobulin: October 2008

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Rabies: Human Rabies Immunoglobulin (HRIG)

Details

Varicella zoster immunoglobulin (VZIG)

For guidance on VZIG, please see guidance on the use and ordering of varicella zoster immunoglobulin (VZIG).

Tetanus immunoglobulin

For guidance on the treatment of tetanus cases and management of tetanus prone wounds, please see tetanus: guidance for health professionals .

Measles post exposure prophylaxis

For guidance on the use of post exposure prophylaxis for measles in high risk groups please see guidance for measles post-exposure prophylaxis.

Immunoglobulins are concentrated antibody preparations which provide immediate short-term protection against disease for individuals at high risk of severe disease or serious complications from the disease.

These documents contains information, indications and guidance for the use of immunoglobulin preparations for each individual disease.

Published 1 October 2008
Last updated 9 November 2018 + show all updates
  1. Added link to revised guidance for health professionals.
  2. RIgS page updated. VZIG documents removed and link to new VZIG page added to the details section.
  3. Added revised Diphtheria Anti-toxin (DAT) guidance for August 2018.
  4. Added revised Diphtheria Anti-toxin (DAT) guidance updated due to DAT supply.
  5. Added revised interim guidance on the use of Diphtheria anti-toxin.
  6. Added document: Updated restrictions on use of VZIG during supply shortage: advice to health professions and RIgs page updated.
  7. Updated to reflect Greenbook changes in Human Rabies Immunoglobulin (HRIG) guidance.
  8. Uploaded interim VZIG guidance for pregnant women exposed to varicella, in relation to current immunoglobulin shortages.
  9. Added details of VZIG restrictions due to shortage.
  10. Updated Chickenpox (varicella-zoster) immunoglobulin guidance to clarify dose of methotrexate on page 10.
  11. Updated hepatitis A immunoglobulin guidance to clarify dosage and timing details.
  12. Updated 'Chickenpox (varicella-zoster) immunoglobulin May 2017' guidance by adding 'methotrexate' to table on page 12.
  13. Updated Chickenpox (varicella-zoster) immunoglobulin guidance.
  14. Updated rabies and immunoglobulin service guidance.
  15. Updated Chickenpox human varicella-zoster immunoglobulin guidance
  16. Details on an update to the Rabies and Immunoglobulin Service (RIgS).
  17. Updated the diphtheria anti-toxin chapter: the dosage section on page 1 has changed, based on WHO guidance and may differ from the Summary of Product Characteristics (SmPC).
  18. First published.