Published 1 October 2008
Last updated 14 November 2023
+ show all updates
14 November 2023
Updated Post-exposure for non-responders section in Hepatitis B immunoglobulin.
26 September 2023
Updated 'Hepatitis B immunoglobulin'.
26 September 2022
Updated hepatitis B immunoglobulin.
4 May 2022
Updated Diphtheria anti-toxin: clinical guidance.
2 November 2021
Removed 'Important information about the Intervax diphtheria anti-toxin Lot 146 and extended use' as no longer applicable.
17 September 2021
Updated Rabies and Immunoglobulin Service information.
17 March 2021
Added updated guidance on the use of diphtheria anti-toxin.
4 March 2021
Added Hepatitis B immunoglobulin: March 2021.
2 October 2020
Added revised guidance on the use of diphtheria anti-toxin, October 2020
3 September 2020
Added: Important information about the Intervax diphtheria anti-toxin Lot 146 and extended use.
28 August 2020
Updated general immunoglobulin information.
26 August 2020
Updated Rabies and Immunoglobulin Service (RIgS).
14 October 2019
Updated 'Rabies and Immunoglobulin Service: use of approved courier services'.
8 July 2019
Added revised hepatitis B immunoglobulin guidance.
19 June 2019
Added revised Hepatitis A immunoglobulin guidance.
9 November 2018
Added link to revised guidance for health professionals.
14 September 2018
RIgS page updated. VZIG documents removed and link to new VZIG page added to the details section.
23 August 2018
Added revised Diphtheria Anti-toxin (DAT) guidance for August 2018.
22 August 2018
Added revised Diphtheria Anti-toxin (DAT) guidance updated due to DAT supply.
16 August 2018
Added revised interim guidance on the use of Diphtheria anti-toxin.
8 August 2018
Added document: Updated restrictions on use of VZIG during supply shortage: advice to health professions and RIgs page updated.
16 July 2018
Updated to reflect Greenbook changes in Human Rabies Immunoglobulin (HRIG) guidance.
12 July 2018
Uploaded interim VZIG guidance for pregnant women exposed to varicella, in relation to current immunoglobulin shortages.
9 July 2018
Added details of VZIG restrictions due to shortage.
21 August 2017
Updated Chickenpox (varicella-zoster) immunoglobulin guidance to clarify dose of methotrexate on page 10.
29 June 2017
Updated hepatitis A immunoglobulin guidance to clarify dosage and timing details.
7 June 2017
Updated 'Chickenpox (varicella-zoster) immunoglobulin May 2017' guidance by adding 'methotrexate' to table on page 12.
30 May 2017
Updated Chickenpox (varicella-zoster) immunoglobulin guidance.
14 March 2017
Updated rabies and immunoglobulin service guidance.
11 October 2016
Updated Chickenpox human varicella-zoster immunoglobulin guidance
27 April 2016
Details on an update to the Rabies and Immunoglobulin Service (RIgS).
14 April 2016
Updated the diphtheria anti-toxin chapter: the dosage section on page 1 has changed, based on WHO guidance and may differ from the Summary of Product Characteristics (SmPC).
1 October 2008