Guidance

Immunoglobulin: when to use

PHE's immunoglobulin handbook, providing guidance on administering immunoglobulin to prevent serious disease.

Documents

Hepatitis A immunoglobulin: June 2017

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Rabies and immunoglobulin service (RIgS)

General product information and how to administer immunoglobulin: July 2014

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Chickenpox (varicella-zoster) immunoglobulin: August 2017

Diphtheria anti-toxin: June 2017

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Hepatitis B immunoglobulin: October 2008

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Babies of hepatitis B infected mothers: August 2008

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Mumps and immunoglobulin: October 2008

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Polio immunoglobulin: October 2008

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Human rabies immunoglobulin: July 2014

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Details

Immunoglobulins are concentrated antibody preparations which provide immediate short-term protection against disease for individuals at high risk of severe disease or serious complications from the disease.

This handbook contains information, indications and guidance for the use of immunoglobulin preparations for each individual disease.

See guidance for measles post-exposure prophylaxis and recommendations on treatment and prophylaxis for tetanus.

Published 1 October 2008
Last updated 21 August 2017 + show all updates
  1. Updated Chickenpox (varicella-zoster) immunoglobulin guidance to clarify dose of methotrexate on page 10.
  2. Updated hepatitis A immunoglobulin guidance to clarify dosage and timing details.
  3. Updated 'Chickenpox (varicella-zoster) immunoglobulin May 2017' guidance by adding 'methotrexate' to table on page 12.
  4. Updated Chickenpox (varicella-zoster) immunoglobulin guidance.
  5. Updated rabies and immunoglobulin service guidance.
  6. Updated Chickenpox human varicella-zoster immunoglobulin guidance
  7. Details on an update to the Rabies and Immunoglobulin Service (RIgS).
  8. Updated the diphtheria anti-toxin chapter: the dosage section on page 1 has changed, based on WHO guidance and may differ from the Summary of Product Characteristics (SmPC).
  9. First published.