Newborn blood spot screening programme: supporting publications

Guidance and resources for health professionals and commissioners working in the NHS newborn blood spot (NBS) screening programme.

The NHS newborn blood spot (NBS) screening programme helps identify several rare but serious diseases with a small blood sample, also called a heel prick test.

See Newborn screening: information leaflets for digital information leaflets for health professionals to use in conversations with parents to explain NBS tests, possible results and follow-up tests.

Programme pathway

Screening guidance


Congenital hypothyroidism (CHT)

Health professionals should refer to CHT suspected: description in brief and CHT further information for families in conversations with parents following positive screening test results.

Cystic fibrosis (CF)

Health professionals should refer to Cystic fibrosis suspected: description in brief and Cystic fibrosis carrier: description in brief as appropriate in conversations with parents following positive screening results.

Inherited metabolic diseases (IMDs)

Sickle cell disease

SCID screening evaluation

Information for the public and professionals to support the evaluation of screening for severe combined immunodeficiency (SCID) in England.

Screening for SCID is being offered in some parts of England as part of an evaluation. It is not yet available for all newborn babies in England. See the PHE Screening blog for more information.

Published 1 July 2012
Last updated 3 September 2021 + show all updates
  1. Updated information relating to SCID screening evaluation.

  2. Added updated letter templates to the SCID screening evaluation section.

  3. Updated the 'SCID evaluation' section with new resources.

  4. Added a new section on SCID.

  5. Addition to collection of 'Newborn blood spot screening: reporting positive results from laboratories'

  6. Removal of public information leaflets from collection with addition of links signposting to Newborn screening: information leaflets collection.

  7. Added newborn blood spot screening care pathway.

  8. Added 'Congenital hypothyroidism: initial clinical referral guidelines'.

  9. Added 'sickle cell disease: positive result referral template letter' to document collection.

  10. Added failsafe publications.

  11. Added PKU not suspected, other disorder follow up for PKU team letter template.

  12. First published.