Cystic fibrosis: screening laboratory handbook

This document explains the guidelines for laboratories screening newborns for cystic fibrosis (CF) in the UK.


A laboratory guide to newborn screening in the UK for cystic fibrosis

This file may not be suitable for users of assistive technology. Request an accessible format.

If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email Please tell us what format you need. It will help us if you say what assistive technology you use.


This handbook sets out laboratory standards and guidelines for cystic fibrosis (CF) screening in newborn babies.

The document includes:

  • national procedures for screening laboratories
  • form for notification of presumptive positive by the screening laboratory to a clinician
  • template letter to inform general practitioners and the child health records department of incomplete screening

Addendums to CF laboratory handbook

  1. On page 15, section 5.1:

For sets of three results which are considered to be discrepant: Points a and b should be a combined sentence.

Published 1 February 2014