Isotretinoin for severe acne: uses and effects

How isotretinoin is used, its side effects, psychiatric effects and use during pregnancy.


Review of isotretinoin and psychiatric adverse reactions

This file may not be suitable for users of assistive technology.

Request an accessible format.
If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email Please tell us what format you need. It will help us if you say what assistive technology you use.


This Medicines and Healthcare Products Regulatory Agency (MHRA) guidance for healthcare professionals covers:

  • prescribing
  • side effects
  • use during pregnancy
  • psychiatric effects
Published 18 December 2014