Isotretinoin for severe acne: uses and effects

How isotretinoin is used, its side effects, psychiatric effects and use during pregnancy.

This publication was withdrawn on

The 2014 guidance on isotretinoin has been withdrawn.

From October 2023, healthcare professionals to consult the October 2023 Drug Safety Update and Report of the Isotretinoin Implementation Advisory Expert Working Group when referring patients and when prescribing or dispensing isotretinoin. Patients should consult the isotretinoin Patient Information Leaflet or the isotretinoin Patient Guide



This Medicines and Healthcare Products Regulatory Agency (MHRA) guidance for healthcare professionals covers:

  • prescribing
  • side effects
  • use during pregnancy
  • psychiatric effects
Published 18 December 2014