Rabies: risk assessment, post-exposure treatment, management
Guidance on assessing risk following rabies exposure, post-exposure treatment, and public health management of a suspected rabies case in the UK.
Advisory notices have been raised by the Philippines Food and Drug Administration regarding the distribution of falsified rabies vaccines in the Philippines. The falsified vaccines were relabelled as Speeda and Vaxirab-N vaccines.
The UK Health Security Agency (UKHSA) is undertaking a review of the records of individuals who have received rabies vaccine as part of their post-exposure treatment course in the Philippines, and is in the process of contacting GPs if their patients are recommended to receive additional vaccines to complete their post-exposure treatment course. Health care professionals with concerns about a patient who may have received falsified rabies vaccine in the Philippines can contact the UKHSA Rabies and Immunoglobulin Service (RIgS) for further advice.
Interim recommendations for the use of human rabies immunoglobulin were issued on 27 June 2025. These recommendations supersede guidance on the use of rabies immunoglobulin within the UKHSA guidelines on managing rabies post-exposure treatment. The current guidance on use of rabies vaccine for post-exposure treatment remains the same.
Rabies is an encephalitis caused by rabies virus, a member of the rhabdovirus family. It is an acute viral infection that is almost invariably fatal once symptoms develop.
Transmission is generally through the bite of an infected animal, usually dogs, but also cats, bats and other wildlife. A course of rabies vaccination can prevent infection and death.
It is important that a medical practitioner assesses all animal bites, especially:
- bat bites in the UK
- any other animal bites overseas
Diagnosis of rabies in the early stages is often difficult as symptoms may be non specific.
Clinical rabies is a notifiable disease in England.
See:
For further assistance
Please contact the Rabies and Immunoglobulin service or your local health protection team. The Rabies and Immunoglobulin service is for healthcare professionals only. Members of the public should contact their GP or local health protection team.
Rabies epidemiology
Rabies post-exposure treatment guidelines
Rabies pre-exposure prophylaxis (non-travel)
This form is only for non-travel related pre-exposure rabies vaccine requests.
Updates to this page
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Added information on Philippines rabies vaccine alert.
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Added information on Indian rabies vaccine alert.
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Removed text about falsified vaccine in Zimbabwe and added notice of interim recommendations.
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Added information on Zimbabwean rabies vaccine alert.
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Removed alert about rabies in a dog in France.
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Added alert about rabies in a dog in France.
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Removed section on rabies confirmed in a cat in Italy.
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Added an alert about rabies in a cat in Italy.
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Added an alert about rabies in a dog in France.
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Added post-exposure guidance for timing of vaccine boosters.
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Updated the alert on falsified rabies vaccines being used in the Philippines.
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Added 'Rabies: risks for travellers' document, and a new alert on falsified rabies vaccines being used in the Philippines.
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Removed alert regarding falsified rabies vaccine in the Philippines, because PHE has completed public health actions in England.
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Added alert regarding falsified rabies vaccine in the Philippines.
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Added Rabies epidemiology transmission and prevention.
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Added Rabies: risks from bat bites.
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Added rabies special edition of Vaccine Update.
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Added link to updated rabies chapter of the Green Book.
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Added new guidance on 'Rabies: administration of vaccine and immunoglobulin' to 'Rabies post-exposure treatment guidelines' section.
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Added guidelines for requesting pre-exposure prophylaxis
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Added request form for pre-exposure vaccine (non-travel).
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Updated rabies post exposure risk assessment form and calendar (v19) and new letter for rabies vaccine and immunoglobulin batch SRC16187.
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Added guidance for administration of rabies immunoglobulin.
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Updated to include 'Rabies vaccine and immunoglobulin: administering Ig SRCN0820.
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Updated to include 'Rabies vaccine and immunoglobulin: administering Ig BP08947111P'.
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Updated to include 'Rabies vaccine and immunoglobulin: administering Ig SRCN0510'.
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First published.