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This publication is available at https://www.gov.uk/government/publications/immunoglobulin-when-to-use/rabies-and-immunoglobulin-rigs-changes-to-the-current-service
The Rabies and Immunoglobulin Service (RIgS) at Colindale supports the post-exposure treatment of serious infections, through the development of guidance, provision of clinical advice and issuing of immunoglobulins and antitoxins following a detailed risk assessment. This includes post exposure treatment for rabies, chickenpox, hepatitis B, measles and hepatitis A as well as clinical management of botulism and diphtheria. RIgS comprise a multi-disciplinary team of medical doctors, nurses, a business manager and administrative support.
Immunoglobulins and anti-toxins are rare products that are centrally procured by PHE from a range of manufacturers. Stock is held at Movianto, UK on behalf of PHE, but also at Colindale and a number of stockholders distributed throughout the country. RIgS is a busy service; in the financial year 2017 to 2018 there were over 3,500 calls; over 2,000 related to post-exposure treatment (vaccine and/or human rabies immunoglobulin), over 800 calls for rabies pre-exposure advice or prophylaxis, over 300 calls relating to varicella zoster, and over 100 for human normal immunoglobulin for either measles or hepatitis A.
RIgS operates between 9am-5pm Monday to Friday. All requests for stock and advice about issuing should be directed to this service (Tel: 020 8327 6204).
Requests for immunoglobulin/vaccine received before 1pm Monday-Friday will be ordered through Movianto for delivery to a named responsible clinician to arrive the next working day. Requests received after 1pm cannot be ordered/requested until the next working day. (Ordering of immunoglobulin/vaccine on a Friday will only be possible if the delivery address is open on a Saturday. If this is not the case a courier would need to be arranged for pick up from Colindale or the issue would need to wait until the next working day).
Where product is needed sooner, PHE can issue vaccine/ immunoglobulin/anti-toxin from Colindale during working hours for providers to collect using a courier service (paid by the provider). The Colindale site is open for collection 24 hours a day, seven days a week.
Alternatively, in some cases vaccine/immunoglobulin/anti-toxin may be able to be collected from the nearest stock-holder – RIgS can provide the contact details.
PHE can issue products from Colindale between 2 and 3pm at weekends and bank holidays for the requestor to arrange collection (generally using a courier). Therefore, for the majority of patients, arrangements should be made for collection and administration of the immunoglobulin the next day.
Requests to issue products at other times will only be considered where there is an immediate threat to life. This would be for botulinum and diphtheria anti-toxin or in the case of rabies post-exposure only for a Red composite rabies risk in a previously untreated rabies exposure to the head and neck. VZIG, HBIG, and HNIG will not be issued outside the designated time slots.
PHE cannot issue products for administration to patients outside of England and Wales.