Guidance

Mutagenicity of alcohol (ethanol) and its metabolite acetaldehyde

A statement from the Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM).

Documents

Statement on the mutagenicity of alcohol (ethanol) and its metabolite acetaldehyde: update on information published between 2000 and 2014

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COM statement 2015 S2 on mutagenicity of alcohol: supporting papers

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Detail

This statement details the conclusions reached by the COM with regard to the published evidence on the genotoxicity and mutagenicity of ethanol, acetaldehyde and alcoholic beverages from January 2000 to May 2014, including the modifications made to the conclusions drawn in 2000.

It includes a discussion of the role of reactive oxygen species and other metabolites in the genotoxicity and mutagenicity of alcohol.