Collection

Committee on Mutagenicity: statements and guidance

Guidance and recommendations from the Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM).

• From: Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment
• Published: 1 December 2012
• Last updated: 12 March 2020 — See all updates

The Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM) has a general remit to advise on important general principles or new scientific discoveries in connection with:

• mutagenic and genotoxic hazards (the inherent property of the substance)
• risk (the likelihood of mutagenic or genotoxic effects occurring after exposure)

These statements and guidance documents present COM’s conclusions on these topics.

Older publications can be found on the National Archives website.

Guidance statements

• The significance of chemical-induced mutation for human health
  • 1 July 2012
  • Guidance
• A strategy for testing of chemicals for genotoxicity
  • 22 December 2021
  • Guidance
• Genotoxicity assessment of impurities in chemical substances
  • 1 April 2012
  • Guidance
• Assessment of thresholds for in vivo mutagens
  • 1 April 2010
  • Guidance

Statements

• Epigenetics in chemical risk assessment: joint committee statement
  • 12 March 2020
  • Guidance
• Statement on the use of mutation spectra in genetic toxicology
  • 16 February 2016
  • Guidance
• Mutagenicity of alcohol (ethanol) and its metabolite acetaldehyde
  • 8 January 2016
  • Guidance
• Statement on photogenotoxicity testing
  • 1 July 2013
  • Guidance

Annual reports

Annual reports from 2012 and earlier are available from the National Archives.

• Committees on Toxicity, Mutagenicity, Carcinogenicity of Chemicals in Food, Consumer Products and the Environment: joint annual report
  • 20 December 2023
  • Corporate report

Published 1 December 2012
Last updated 12 March 2020 + show all updates

1. 12 March 2020

   Added Epigenetics in chemical risk assessment: joint committee statement.

2. 16 February 2016

   Added statement on the use of mutation spectra in genetic toxicology.

3. 6 January 2016

   Added statement on mutagenicity of alcohol and its metabolite acetaldehyde.

4. 1 December 2012

   First published.