Guidance

A strategy for testing of chemicals for genotoxicity

Five guidance statements on testing chemicals with no or inadequate genotoxicity data.

From:
Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment
Published
1 December 2011
Last updated
22 December 2021 — See all updates

Documents

Guidance on a strategy for genotoxicity testing of chemicals

Ref: Ref COM/G strategy – Version 4.0 (2021)

PDF, 562 KB, 74 pages

This file may not be suitable for users of assistive technology.

Request an accessible format.
If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email com@phe.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

Guidance on a strategy for genotoxicity testing of chemical substances: prescreening considerations

Ref: Ref COM/G0 – Version 2.0 (2021)

PDF, 86.7 KB, 3 pages

This file may not be suitable for users of assistive technology.

Request an accessible format.
If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email com@phe.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

Guidance on a strategy for genotoxicity testing of chemical substances: in vitro assessment

Ref: Ref COM/G1 – Version 2.0 (2021)

PDF, 382 KB, 38 pages

This file may not be suitable for users of assistive technology.

Request an accessible format.
If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email com@phe.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

Guidance on a strategy for genotoxicity testing of chemical substances: in vivo testing

Ref: Ref COM/G2 – Version 2.0 (2021)

PDF, 325 KB, 32 pages

This file may not be suitable for users of assistive technology.

Request an accessible format.
If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email com@phe.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

Guidance on mutagenic hazard assessment and a strategy for genotoxicity testing of chemicals with inadequate genotoxicity data

PDF, 67.8 KB, 10 pages

This file may not be suitable for users of assistive technology.

Request an accessible format.
If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email com@phe.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

Details

These statements set out the recommendations of the Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM). They include:

  • a 3-stage strategy for testing chemicals with no existing genotoxicity data
    • recommendations for stage 0: prescreening considerations prior to testing
    • recommendations for stage 1: a strategy for in vitro assessment
    • recommendations for stage 2: a strategy for in vivo testing
  • a final stage of recommendations for chemicals with inadequate genotoxicity data
Published 1 December 2011
Last updated 22 December 2021 + show all updates

  1. Updated guidance documents.

  2. First published.

Related content