Guidance

A strategy for testing of chemicals for genotoxicity

5 guidance statements on testing chemicals with no or inadequate genotoxicity data.

Documents

Guidance on a strategy for genotoxicity testing of chemical substances

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Guidance on a strategy for genotoxicity testing of chemical substances: prescreening considerations

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Guidance on a strategy for genotoxicity testing of chemical substances: in vitro assessment

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Guidance on a strategy for genotoxicity testing of chemical substances: in vivo testing

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Guidance on mutagenic hazard assessment and a strategy for genotoxicity testing of chemicals with inadequate genotoxicity data

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Details

These statements set out the recommendations of the Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM). They include:

  • a 3-stage strategy for testing chemicals with no existing genotoxicity data
    • recommendations for stage 0: prescreening considerations prior to testing
    • recommendations for stage 1: a strategy for in vitro assessment
    • recommendations for stage 2: a strategy for in vivo testing
  • a final stage of recommendations for chemicals with inadequate genotoxicity data
Published 1 December 2011