Drug misuse and dependence: UK guidelines on clinical management

How clinicians should treat people with drug misuse and drug dependence problems.



Often called the Orange Book, this is guidance for clinicians treating people with drug problems.

This 2017 version offers new guidelines on:

  • prison-based treatment
  • new psychoactive substances and club drugs
  • mental health co-morbidity
  • misuse of prescribed and over-the-counter medicines
  • stopping smoking
  • preventing drug-related deaths, including naloxone provision

The new guidelines also have a stronger emphasis on recovery and a holistic approach to the interventions that can support recovery.

Updates to this page

Published 14 July 2017
Last updated 15 December 2017 + show all updates
  1. Updated with latest version of guidelines.

  2. First published.

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