Transparency data

Non-tech. summaries 2015: projects on the nervous system

Projects granted during 2015 with a primary purpose of basic research: nervous system.

Documents

Non-technical summaries: projects granted in 2015, volume 19

This file may not be suitable for users of assistive technology. Request an accessible format.

If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email alternativeformats@homeoffice.gsi.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of basic research: nervous system.

The following projects were granted:

  • brain plasticity with experience and recovery (plasticity, learning, stroke, exercise, experience)

  • neuronal network activity underlying behaviour (brain, neuron, plasticity, cognition, neuromodulator)

  • neural mechanisms in health and disease (neurophysiological function, neurophysiological dysfunction, ageing)

  • circuit mechanisms governing network oscillations (septum, cortex, oscillations, theta, synapses)

  • affect and cognition in rodents (affect, cognition, consumption, microstructure)

  • role of neuroinflammation in depression and cognition (depression, inflammation, inflammasome)

  • genetically modified rodent models of neurodegeneration (alzheimer’s; parkinson’s, motor neuron disease; transgenic rodents; novel therapeutics)

  • delta-protocadherins in cortical development (cortex, development, delta-2 protocadherins, Pcdh19, EFMR)

  • plasticity and function of the visual system (primary visual cortex; amblyopia; neurodevelopmental disorders; glaucoma)

  • brain systems for rodent memory (brain, systems, rodent, memory)

  • genetic and functional studies in neurodegenerative disease (neurodegeneration, alzheimer disease, down syndrome, motor neuron diseases, mouse)

  • drug modification of opioid tolerance (opioid: tolerance: respiratory depression)

  • novel imaging applied to the study of memory (learning, memory, imaging, synaptic plasticity, optics)

  • bioenergetics of the nervous system (bioenergetics, mitochondria, inflammation, demyelination, neurodegeneration)

  • support procedures for neuroscience studies (transgenic, behaviour, substances, tissue)

  • neuropharmacology of vulnerability to compulsivity (addiction, compulsivity, vulnerability, neuropharmacology, rat)

  • rodent models of neurodegenerative disease (huntington’s disease, cognition, locomotion, mice)

  • spinal cord injury and repair (spinal cord; plasticity; regeneration; rehabilitation)

  • mechanisms of myelination and synapse formation (epilepsy, neuropathy, genetic programme)

  • blood vessels in cortical interneuron development (neocortex, interneurons, development, migration, blood vessels)

  • neurophysiology of reward (brain1 neurons, reward, learning, decision making)

  • investigating the neural basis of spatial and episodic memory (memory, episodic, alzheimer’s, hippocampus, behaviour)

  • epigenetic regulation of neuronal development (brain, development, neurodegeneration, transcription)

  • neuronal networks and pathways for communication (communication, neuroimaging, neurophysiology, primate, neuronal mechanisms)

  • molecular pathogenesis of neurodegeneration (alzheimer’s O-GlcNAcylation neuropathology)

  • neuronal and sensory functions of tmc genes (sensory transduction, taste, touch, hearing)

  • mechanisms of perinatal brain injury (preterm, term, hypoxia-ischaemia, inflammation, translational)

  • cognitive-enhancing properties of nicotine and related psychoactive substances (nicotine, attention, withdrawal, dependence)

  • mechanism of brain function and malfunction (cognition, cell assemblies, EEG, dementia, transgenes)

  • neuronal activity underlying sensory behaviour (brain, electrophysiology, imaging, information processing, somatosensory)

  • GABAAR, neurosteroids and stress in brain function (GABA, neurotransmission, stress, depression, addiction)

  • investigation of the in vivo action of G protein coupled receptors (neurodegeneration, physiology, drugs, cancer, diabetes)

  • biological and psychological bases of addiction (drug abuse, transgenic mice, behaviour)

  • characterisation of novel therapeutics (drug discovery)

  • studying central nervous system repair (multiple sclerosis, cerebral palsy, central nervous system, repair, oligodendrocyte)

  • studying myelinated axons in vivo using zebrafish (zebrafish, in vivo imaging, nervous system development)

  • zebrafish models of movement disorders (parkinson’s disease, mitochondria, dopaminergic neurons, parkin, PINK1)

  • post-operative cognitive decline: pathogenesis & protection (surgery; neuroinflammation; cognition; dementia; alzheimer’s)

  • genetic analysis of axon guidance and maintenance (breeding, transgenic, neurodegeneration)

  • analysis of fish development (eye, brain, stem cells, zebrafish)

  • blood flow and tissue oxygenation in rodents (haemodynamic response, imaging, pre-clinical models)

  • biological and psychological bases for addictions (drug abuse, transgenic mice, behaviour)

  • molecular & cellular correlates of stress-induced behaviour (GABA, mental illness, noradrenaline, serotonin, emotion)

  • neuronal circuitry of the spinal dorsal horn (pain, itch, spinal cord, interneuron, projection neuron)

  • cellular functions of myosin motor proteins (cell function, neurodegeneration, transport)

  • perioperative medicine related uses of anaesthetics (rodent; anaesthetics, noble gas; brain injury; cancer)

  • cerebrovascular changes in the aged and diseased brain (ageing, alzheimer’s disease, blood vessel)

  • synaptic plasticity in normal learning and addiction (memory, hippocampus, accumbens, opioid, heroin)

  • misfolded protein and neurodegenerative disease (prion, amyloid, seeding, neurodegeneration, TSE)

  • neuronal and glial AMPA and GABAA receptors in health and disease (synaptic transmission; neurons: neurological disease)

  • studies to find improved treatments for movement disorders (parkinson’s disease dystonia neurodegeneration neuroprotection symptomatic treatment)

  • neurovascular coupling in health ageing and disease (neurovascular coupling, dementia, ageing, epilepsy)

  • animal models of neurodevelopmental disorders (rat, behaviour, pregnancy, gut, brain)

  • antibodies to neuropeptidergic signalling molecules (antibody neuropeptide evolution echinoderm)

  • basic mechanisms of chronic neurodegeneration (TSE, neurodegeneration, mouse models)

  • connectivity and plasticity of developing and mature central nervous system circuits (brain development, neurons, synapses, axons)

  • structural and functional plasticity in cortex (brain, plasticity, degeneration, synapses, learning)

  • studying a human neurological disease-causing gene (epilepssy, motor neuron disease, autism)

  • spinal sensory processing (somatosensory, dorsal root ganglion, spinal, analgesia)

  • the role of neuropeptides in behaviour (vasopressin, oxytocin, social behaviours)

  • memory in the rat (memory, learning)

  • neural basis on spatial learning and memory (neural, spatial, learning, memory)

  • the neural basis of spatial cognition and memory (rat, mouse, single neurons, behaviour, spatial memory, navigation)

  • mechanisms contributing to analgesic use & misuse (opioid, GABA, neurotransmission, stress, nociception)

  • functions of the murine trappc9 gene (brain development, stem cells, microcephaly)

  • mechanism-based targets for new analgesics (analgesia, molecular targets, somatosensory, sensitisation)

  • encoding behaviour from synapses to circuits (behaviour, neurons, communication, brain, experience)

  • understanding successful brain repair in zebrafish (traumatic brain injury, tissue repair)

  • ion channel function and epileptogenesis (ion channels, epilepsy, brain)

  • neuroprotective treatments for traumatic injury (neuroprotection, spinal cord injury, regeneration, nerve injury, repair)

  • repairing the damaged peripheral nerve (sciatic nerve, axon regeneration, neuroprotection, scarring, nerve conduits)

  • cell-specific chromatin profiling in mouse cortex (cerebral cortex development; targeted DamID)

  • the role of central sympathetic control neurones (cardiovascular control, paraventricular nucleus)

  • the molecular and cellular mechanisms that underpin cns plasticity (stem cells, myelin, regeneration)

  • recovery of peripheral nerve function (nerve, bladder, physiology)

Published 24 June 2016