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Non-tech. summaries 2015: projects on the endocrine system

Projects granted during 2015 that have a primary purpose of basic research: the endocrine system.

From:
Home Office
Published
28 June 2016

Documents

Non-technical summaries: projects granted in 2015, volume 26

PDF, 389 KB, 46 pages

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of basic research: the endocrine system/metabolism.

The following projects were granted:

  • mouse models of calcium and bone disorders (calcium homeostasis, bone dysplasias, parathyroid, kidney)

  • breeding and maintenance of genetically modified and mutant mice (mice, genetically modified, breeding, mutant)

  • discovery of healthy lean gene mechanisms (genes, healthy leanness, obesity, diabetes)

  • genetic control of endocrine development and tumorigenesis (pituitary, hormones, birth defects, tumours, genetics)

  • metabolism, pharmacokinetics and biomarkers (metabolism, pharmacokinetics, biomarkers, DMPK)

  • the origin of new β-cells in pregnancy (β-cells, pregnancy, transdifferentiation, 4OHT, transgenic)

  • cancer Pathways in Metabolic Disease (Metabolism, cancer, signalling pathways, therapy)

  • the physiological role of B3 vitamins in energy metabolism (energy, vitamin B31 nicotinamide adenine dinucleotide, mitochondria)

  • circadian control of behaviour and metabolism (obesity, diabetes, clock, biological rhythms, physiology)

  • embryogenesis, stem cells and cell fate decisions (stem cells, cell fate, embryogenesis)

  • extracellular regulation of insulin resistance (iInsulin, obesity, type 2 diabetes)

  • the mechanisms of ageing and age-related disease (ageing, age-related disease, healthspan)

  • endocrine action and endocrine cancer therapy (androgens, prostate, cancer, endocrine)

Published 28 June 2016

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