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Non-tech. summaries 2015: projects on multisystemic research

Projects granted during 2015 that have a primary purpose of multisystemic research.



This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of multisystemic research.

The following projects were granted:

  • molecular basis of vertebrate development (mouse, DNA binding proteins, signalling pathway, knockout, transgenic)

  • genetics of behaviour and stress response in fish (genetics, stress, evolution, fish, behaviour)

  • brain mechanisms regulating cardiovascular homeostasis in health and disease (brain, mechanisms, regulating, cardiovascular homeostasis, health, disease)

  • breeding, freezing and recovering genetically modified mice (breeding, freezing, genetically modified, mice)

  • mechanisms of stem cell differentiation in fish (transgenic fish, embryo development, gene function)

  • pre-treatment and monitoring of the organ donor to improve graft function for transplantation (donation, transplant, kidney, liver, ischemia)

  • in vivo studies of ADP-ribosylation signalling (ADP-ribosylation, post-translational modification (PTM))

  • health of aged cloned sheep (health, aged, cloned, sheep)

  • functional analysis of factors implicated in X chromosome inactivation (gene regulation, X chromosome, chromatin)

  • pathways of gut health and inflammation (gut, ageing, inflammation, microorganisms)

  • organ dysfunction following acute illness (intensive care, sepsis, organ failure)

  • DNA Strand Breaks, DNA damage responses, and disease (DNA damage, neurodegeneration, cancer)

  • study of changes which occur during ageing (healthy ageing connective tissue crosslinks)

  • models of viral hepatitis (hepatitis, virus, treatment)

  • oxidative stress and ageing (oxidative stress, degenerative disease, ageing)

  • mouse membrane traffic mutants (basic science, human disease)

  • genetic analysis of stem cells using the mouse (stem cells, mouse, genetics)

  • breeding and production of genetically altered mice (genetic alteration, mouse, breeding)

  • investigation of the in vivo action of G protein coupled receptors (neurodegeneration, physiology, drugs, cancer, diabetes)

  • cell signalling in neural and cardiovascular development and regeneration (blood vessel growth, nerve regeneration)

  • study of infection and antibiotic resistance (antibiotics, bacteria, resistance)

  • regulation of mammalian hox genes (mouse, hox, gene regulation, enhancer elements)

  • DNA damage response involvement in genome stability and cancer (DNA damage, genome stability, cancer)

  • molecular regulation of development (development, zebrafish, embryo, mechanism)

  • investigating the pharmacology of traditional and nanoformulated medicines (pharmacokinetics, nanoformulation, bioavailability, tissue distribution)

  • utilising MRI to probe physiological state (MRI, contrast agent, diagnosis, disease)

  • podoplanin-CLEC-2 in sepsis and haemolytic uremic syndrome (CLEC-2, podoplanin, sepsis, HUS)

  • fungal infection, diagnosis and therapy (fungus, infection, anti-fungal, therapy, diagnosis)

  • nuclear reprogramming by xenopus eggs and oocytes (nucleus, reprogramming, xenopus)

  • complex mammalian responses to alkylating agents (DNA damage, DNA repair, metabolism, alkylation)

  • polyclonal antibody development (polyclonal, antibody, immunisation, rabbit, sheep)

  • mechanism underlying diet induced metabolic disorders (high fructose, high fat, sucrose, ketohexokinase, NAFLD)

  • pathophysiology of the unfolded protein response (protein misfolding, endoplasmic reticulum, unfolded protein response protein chaperones, diseases of ageing

  • immunobiology of mycobacterial infection (tuberculosis, mycobacterium, vaccines, chemotherapy)

  • understanding how parasitic worms (roundworms) have evolved and developing new drugs to treat diseases caused by them (parasite, trichinella, novel drugs, anthelmintics)

  • immune regulation of tissue repair in ageing (immunity, senescence, ageing)

  • control of central nervous system autoimmunity (multiple sclerosis, neuroprotection, repair, autoimmunity, spasticity)

  • studying macrophage plasticity in inflammatory disease (macrophages, inflammatory disease, genomics/genetics)

  • regulation of cell polarity in vertebrate development (embryo, development, cells, regenerative medicine)

  • treatment of abnormal retinal development (mice, albinism, L-DOPA, treatment, vision)

  • blocking senescence in ageing (ageing)