Clostridioides difficile infection: guidance on management and treatment

Options, agents, recommendations and algorithms for the treatment of Clostridioides difficile (C. difficile) infection.

This publication was withdrawn on

This guidance is out of date and has been superseded by the National Institute for Health and Care Excellence (NICE) guidance for Clostridioides infection: antimicrobial prescribing, known as NG199.


[Withdrawn] Updated guidance on the management and treatment of C. difficile infection

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The antimicrobial treatment recommendations in the existing Public Health England (PHE) Clostridioides difficile: guidance on management and treatment (2013) have been superseded by the National Institute for Health and Care Excellence (NICE) guideline on Clostridioides difficile infection (CDI).

A full update to the current PHE CDI guidelines is planned for later this year. Please continue to refer to the current PHE guidance for:

  • management of life-threatening disease
  • guidance on diagnosis
  • guidance on infection control

Updates to this page

Published 1 June 2013
Last updated 23 July 2021 + show all updates
  1. Added link to new NICE guidelines.

  2. Replaced name 'Clostridium difficile' with 'Clostridioides difficile' to reflect changes in microbial taxonomy.

  3. First published.

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