Clostridioides difficile infection: guidance on management and treatment

Options, agents, recommendations and algorithms for the treatment of Clostridioides difficile (C. difficile) infection.


Updated guidance on the management and treatment of C. difficile infection

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This guidance covers:

  • a summary of the evidence base and the treatment options for mild, moderate, severe and recurring disease
  • description and summary of agents other than metronidazole, vancomycin or fidaxomicin
  • recommendations
  • treatment algorithms

This document supersedes the relevant sections of Clostridioides difficile infection: How to deal with the problem, published in January 2009.

Published 1 June 2013
Last updated 6 September 2019 + show all updates
  1. Replaced name 'Clostridium difficile' with 'Clostridioides difficile' to reflect changes in microbial taxonomy.

  2. First published.