Drug Safety Update

Idiopathic intracranial hypertension (IIH) has been very rarely reported in patients treated with mesalazine. Following a recent review, warnings for IIH are being added to the product information for all mesalazine products…

• Therapeutic area: Emergency medicine and 4 others
• Published: 4 December 2025

The Commission on Human Medicines (CHM) has endorsed changes to isotretinoin prescribing guidance. In addition, CHM is seeking further information from dermatology services who prescribe isotretinoin to inform any future cha…

• Therapeutic area: Dermatology and 4 others
• Published: 27 October 2025

The annual #MedSafetyWeek campaign takes place from 3 to 9 November 2025. This year’s campaign theme is ‘we can all help make medicines safer.’

• Therapeutic area: Anaesthesia and intensive care and 39 others
• Published: 23 October 2025

Patients should be reminded and reassured that there is no evidence that taking paracetamol during pregnancy causes autism in children. Paracetamol is recommended as the first-choice pain reliever for pregnant women, used at…

• Therapeutic area: Anaesthesia and intensive care and 34 others
• Published: 23 September 2025

There is a small increase in the risk of Guillain-Barré syndrome following vaccination with Abrysvo (Pfizer respiratory syncytial virus (RSV) vaccine) and Arexvy (GSK RSV vaccine) in adults aged 60 years and older. Healthca…

• Therapeutic area: Anaesthesia and intensive care and 5 others
• Published: 7 July 2025

Updated safety and educational materials are now available to support the implementation of the regulatory measures announced in the November 2023 National Patient Safety Alert and the September 2024 Drug Safety Update. They…

• Therapeutic area: General practice and 5 others
• Published: 10 June 2025

Psychological side effects such as anxiety, low mood, sleep disturbance, poor concentration, and forgetfulness have been infrequently reported in people with cystic fibrosis treated with Kaftrio. Healthcare professionals sho…

• Therapeutic area: General practice and 2 others
• Published: 7 May 2025

Healthcare professionals and patients are reminded of the risk of severe asthma attacks and increased mortality associated with overuse of SABA with or without anti-inflammatory maintenance therapy in patients with asthma. H…

• Therapeutic area: General practice and 2 others
• Published: 24 April 2025

Fezolinetant treatment is associated with a risk of drug induced liver injury. New recommendations have been introduced to minimise this risk. Liver function should be monitored before and during treatment in all patients ta…

• Therapeutic area: Dispensing GP practices and 2 others
• Published: 10 April 2025