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Non-tech. summaries 2014: projects on the musculoskeletal system

Projects granted during 2014 that have a primary purpose of basic research into the musculoskeletal system.

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2014 with a primary purpose of basic research into the musculoskeletal system.

The following projects were granted:

  • use of tri-axial accelerometers to quantify energies during collision in laying hens (poultry, keel, welfare, production, accelerometer)
  • redox pathways in osteoarthritis (redox pathways; osteoarthritis; DMM; mouse)
  • musculoskeletal ageing and innervation (loading exercise, muscle, bone, innervations)
  • skeletal mechanobiology, remodeling and repair (osteoporosis, osteoarthritis, remodelling, repair, loading)
  • action of equine stem cells in tissue regeneration (horse, stem cells, regenerative medicine)
  • destruction and regeneration of joints in arthritis (cartilage, bone, arthritis, regeneration, healing)
  • animal models for muscular dystrophy (dystroglycan, fukutin related protein, glycosylation, neuromuscular)
  • using zebrafish to understand gene function and develop new therapies for cancer (melanoma, cancer, development, imaging, drug-development)
  • changing the soil: a new approach to treating arthritis (inflammation, fibroblasts, immune response, arthritis)
  • cartilage repair, replacement and regeneration (cartilage repair, replacement and regeneration)
  • identifying new targets for treating muscular dystrophy (muscular dystrophy, macrophages, dystroglycan, muscle)
  • mechanism of statin induced myopathy (statin, myopathy, exercise)
  • genetic basis of skeletal evolution and disease (bone, genetics, development, evolution, disease)
  • evolution of locomotion in amphibians (biomechanics, locomotion, amphibians)
  • gene therapy for neuromuscular and cardiovascular disease (gene therapy, muscle, heart, disease)
  • understanding neuromechanical systems biology (locomotion, motor neuron, mouse, optogenetics, proprioception)
  • genetic mechanisms of craniofacial malformation (craniosynostosis, skull, mutation, development, mouse)