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Non-tech. summaries 2014: projects on other basic research

Projects granted during 2014 that have a primary purpose of other basic research: sensory organs (skin, eyes and ears), forensic enquiries and other research.

From:
Home Office
Published
25 April 2016

Documents

Non-technical summaries: projects granted in 2014, volume 18

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2014 with a primary purpose of basic research: sensory organs (skin, eyes and ears), forensic enquiries and other research.

The following projects were granted:

  • genetics and biology of parasitic nematodes (parasitic nematodes, rodents)

  • Notch-Wnt interaction in embryonic development (Notch, Wnt, endocytosis, pluripotency, stem cells)

  • malaria parasite development and drug discovery (plasmodium, malaria, genetics, antimalarial, mosquito)

  • centrosome biology in mammalian development, ageing and stem cell function (development, stem cells, ageing, cell division)

  • production and maintenance of GA rodents (production, maintenance, genetically altered rodents)

  • generation of transgenic mice for gene manipulation (transgenic, gene targeting, knockout, embryonic stem cells)

  • re-derivation of mouse strains (re-derivation; superovulation; embryo transfer)

  • identification of immunological targets for developing new agents to prevent corneal transplant rejection (immunological, agents, corneal, transplant, rejection)

  • mechanisms of movement generation and inhibition (motor cortex, mirror neurons, movement inhibition, subthalamic nucleus, hyperdirect pathway)

  • responses to centrifuge-induced hypergravity (mouse, biomechanics, posture, gait; locomotion)

  • pharmacokinetics and metabolism studies (metabolism, pharmacokinetics, regulatory, ADME, non-clinical)

  • technical development of preclinical imaging (imaging, non-invasive, quantitative, longitudinal)

  • doping/medication control for British horseracing (anti-doping, medication, equine, detection time, control)

  • neuroimmune interactions (cytokine, brain, liver, microglia, astrocyte)

  • anti-angiogenics in retinal neovascularisation and neuroprotection (retina, angiogenesis, neuroprotection)

  • object recognition by zebrafish visual system (zebrafish, vision, in vivo imaging, classical conditioning)

  • understanding and manipulating proteostasis (neurodegeneration, chaperone, blindness, virus, stem cell)

  • regulation of inflammation in wound repair (chronic wounds, inflammation, diabetes)

  • developing therapies for inner ear disorders (hearing, deafness, balance)

  • vocal and social learning of avian calls (learning, vocalisation, mobbing, birds)

  • eye lens shape and form (eye lens cataract accommodation, radiosensitivity)

Published 25 April 2016

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