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Non-tech. summaries 2014: projects on the gastrointestinal system

Projects granted during 2014 that have a primary purpose of basic research into the gastrointestinal system, including liver.

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2014 with a primary purpose of basic research into the gastrointestinal system, including liver.

The following projects were granted:

  • mouse models of intestinal disease (stem cells, epithelium, inflammation)
  • characterisation of the enteroendocrine axis (enteroendocrine, diabetes, obesity, GLP-1)
  • developing methods to treat liver disease (novel, treatment, bile, production, cells)
  • targeted therapeutic interventions for liver disease (liver, inflammation, fibrosis, therapy)
  • molecular mechanisms of stem cell activation (stem cells, epithelial, activation)
  • Podoplanin-CLEC-2 in inflammatory bowel disease (CLEC-2, Podoplanin, inflammatory bowel disease)
  • mouse models of hepatic fibrosis and therapeutics investigation (mouse, hepatic, fibrosis)
  • modification of gut function by dietary micronutrient intake (diet, micronutrient, metabolism)
  • the microenvironment in organ homeostasis and cancer (liver, skin, cancer, stem cell)
  • imaging of stem cells In organ fibrosis models of tissue regeneration (liver, kidney, stem cell, regeneration, imaging)
  • study and treatment in liver ischaemia reperfusion (ischaemia:reperfusion; mesenchymal stromal cells; liver)