Live attenuated influenza vaccine: responding to cold chain failures

How to handle live attenuated influenza vaccine (LAIV) (Fluenz Tetra®/Flumist®) stored outside the recommended temperature range.

This publication was withdrawn on

This document on the thermo-stability of live attenuated influenza vaccine (LAIV) is no longer valid, following communication with the vaccine manufacturer. Immunisers should now follow the Summary of Product Characteristics.


Responding to cold chain failures involving the live attenuated influenza vaccine (LAIV) (Fluenz Tetra®/Flumist®)

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This information sheet is to assist providers in taking prompt and appropriate action in the handling of live attenuated influenza vaccine (LAIV) (Fluenz Tetra®/Flumist®) that has been stored outside the recommended temperature range. This includes:

  • what to do if LAIV stock has been exposed to temperatures outside of those recommended for storage (2-8°C)
  • information on the stability of the the live attenuated intra-nasal influenza vaccine
  • an incident checklist for handling vaccine stock
Published 21 October 2015