The Foreign and Commonwealth Office (FCO) advise against all travel to the border with Eritrea. See Local travel
There is a general threat from terrorism. See Terrorism.
There is no British Embassy in Djibouti. The British Honorary Consul in Djibouti can offer limited help. If you need consular assistance outside office hours you should contact the British Embassy in Addis Ababa.
Be aware of the risk of banditry if you travel outside the capital city. See Local travel
Piracy is a significant threat in the Gulf of Aden and Indian Ocean. See Sea travel
Take out comprehensive travel and medical insurance before you travel.