Guidance

Sickle cell and thalassaemia screening: handbook for laboratories

These documents set out policy and standards for laboratories working with the sickle cell and thalassaemia (SCT) screening programme.

Documents

Sickle cell and thalassaemia handbook for antenatal laboratories

Sickle cell and thalassaemia handbook for newborn laboratories

Sickle cell and thalassaemia screening: tandem mass spectrometry newborn screening pilot study

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Sickle cell and thalassaemia screening: action values for tandem mass spectrometry screening

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Recommended quality control for newborn screening for sickle cell disease

Recommended quality control for antenatal screening for sickle cell disease

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Details

The handbook for laboratories sets out policy and standards for laboratories and includes contact details for the laboratory support service.

The handbook includes:

  • laboratory working standards
  • testing algorithms
  • referral guidelines
  • risk assessment procedures
  • laboratory support services

The sickle cell and thalassaemia (SCT) screening programme issues laboratory updates between editions of the handbook.

Laboratory professionals working in the newborn screening laboratories should also refer to the other 2 documents in this publication:

  • tandem mass spectrometry (MS) for sickle cell and thalassaemia newborn screening pilot study
  • action values for MS/MS newborn blood spot sickle cell disease screening

These 2 documents include information on the action values to be used in newborn screening laboratories that use MS/MS as their screening method for sickle cell disease. They also include the background and evidence to support the action values.

The UK National Haemoglobinopathy Reference Laboratory (NHRL) in Oxford provides a dedicated sickle cell and thalassaemia laboratory support service for antenatal and newborn laboratories and other healthcare professionals involved in the screening programme.

UK National Haemoglobinopathy Reference Laboratory (NHRL)

UK National Haemoglobinopathy Reference Laboratory
(NHRL)
Oxford

Published 1 October 2012
Last updated 5 December 2017 + show all updates
  1. Updated action values for MS/MS newborn blood spot sickle cell disease screening.
  2. Removed out-of-date 2012 handbook.
  3. Updated handbook for antenatal laboratories for sickle cell and thalassaemia. This is the fourth edition, updating the edition published in October 2012..
  4. Added 'Recommended quality control for antenatal screening for sickle cell disease'.
  5. Added new publication 'Recommended quality control for newborn screening for sickle cell disease'.
  6. Uploaded new document on newborn laboratories for sickle cell and thalassaemia.
  7. Added tandem mass spectrometry documents.
  8. First published.