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Non-tech. summaries 2015: projects on the cardiovascular system

Projects granted during 2015 that have a primary purpose of basic research: cardiovascular, blood and lymphatic system.



This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of basic research: cardiovascular, blood and lymphatic system.

It contains a full list of the 36 projects that were granted.

The projects covered are:

  • investigation of factors influencing heart failure (heart, hypertension, hormones)

  • novel therapeutic approaches to heart disease (heart failure, energetic, metabolism, ischaemia)

  • tissue function and metabolism in cardiac disease (heart function metabolism stem cells)

  • transcriptional regulation of angiogenesis (angiogenesis, cancer, blood vessels, transcription)

  • switching genes on and off in haemopoiesis (gene regulation haemopoiesis)

  • testing of novel compounds (mitochondria, heart, pharmokinetics)

  • ion regulation and cell signalling in cardiac and skeletal muscle (exercise, heart, heart failure, skeletal muscle, sodium)

  • protection after an acute heart attack or stroke (heart, heart attack, stroke, ischaemia, reperfusion injury)

  • regulation/role of the ERK1/2 cascade in the heart (heart failure, cancer therapies, protein kinases, hypertension, hypertrophy)

  • role of the cytoskeleton in cardiovascular diseases (cytoskeleton, platelet, thrombosis)

  • novel treatments for right heart failure (pulmonary artery hypertension, right heart failure, exercise, β-blockers, phosphodiesterase 5 inhibitors)

  • functional characterisation of novel blood genes (zebrafish, blood, stem cells, cancer)

  • inflammation and cardiovascular disease (blood vessel, thrombosis, aspirin, inflammation, heart attack)

  • the long-term effects of prenatal hypoxia on cardiomyocyte function (programming, pre-natal hypoxia, cardiac, mitochondria, myocyte)

  • developmental programming by maternal diet (maternal obesity, pregnancy, metabolic syndrome, diet, developmental programming)

  • imaging of cardiovascular diseases with novel agents and devices (imaging, cardiovascular disease, diagnosis, therapy)

  • autonomic control of cardiac function and rhythm (cardiac function, arrhythmia, autonomic control)

  • regulation of thrombus formation (clotting factors, thrombus formation)

  • modulation of cardioprotection in pathological states (heart attack, diabetes, age, animal research)

  • investigating normal blood development and blood cancer (haematopoiesis, blood stem cell, leukaemia, microenvironment)

  • studies on vascular diseases and repair mechanisms (blood vessel, restenosis, stent, vein graft, endothelium)

  • zebrafish models of cardiovascular development and disease (cardiovascular, angiogenesis, heart, blood flow)

  • mechanisms and therapy for limb ischaemia (limb ischaemia, angiogenesis, arteriogenesis)

  • signalling in normal and abnormal blood cell function (blood, cancer, clotting, bone marrow)

  • control of adrenal development and function (adrenal, steroid, development, disease, differentiation)

  • transverse aortic constriction (TAC) in rodents (heart failure, cardiac hypertrophy, rats, mice)

  • the role of platelets in haemostasis and thrombosis (mice, platelet, thrombosis, haemostasis)

  • redox mechanisms of organ failure in sepsis (sepsis, redox, blood pressure, multi-organ failure, therapy)

  • modelling striated muscle disease in zebrafish (heart, skeletal muscle, popeye genes)

  • mechanisms of platelet-driven disease (platelet, cardiovascular, heart attack, thrombosis)

  • parental nutrition and offspring development (diet, gamete quality, pre-implantation embryo, offspring health, developmental programming)

  • regulation of normal and malignant haemopoiesis (leukaemia, haematology, development, stem cell)

  • targeted gene delivery for haemostasis (blood coagulation, haemophilia, thrombosis)

  • stem cells for blood and tissue repair (blood, blood vessel, repair, transplantation, regeneration)

  • regulation of blood cell generation (blood stem cells, regenerative medicine)

  • zebrafish manipulation to study blood development (haematopoiesis, haematopoietic stem cells (HSCs), zebrafish)

  • preclinical therapies for renal and cardiovascular injury (kidney injury, cardiac injury, muscle damage, blocked blood flow, therapy)