Effectiveness of IPC measures for high prevalence of C. difficile
Rapid systematic review on effectiveness of additional IPC measures to precent spread of C. difficile in periods of high prevalence in health and social care settings.
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This rapid systematic review (search up to 1 September 2025) aimed to identify and summarise evidence relating to infection prevention and control (IPC) measures, in addition to standard IPC practice, to prevent spread of Clostridioides difficile (C. difficile) in the context of high prevalence in health and social care settings.
No evidence was identified that met the inclusion criteria.
This review was commissioned to inform an update of the UKHSA guidance on Clostridioides difficile infection: how to deal with the problem. It represents the available evidence for this review question, but does not include the updated guidance recommendations. The updated guidance has not yet been published. This page will be updated when it is available.