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Research and analysis

COVID-19: PHE laboratory assessments of inactivation methods

PHE has undertaken assessments of inactivation methods against SARS-CoV-2 with further evaluations ongoing.

Updates to this page

From:
Public Health England
Published:
8 July 2020
Last updated:
4 May 2021
Show all updates

  1. Added 11 SARS-CoV-2 inactivation testing interim reports.

  2. Added 12 new reports and updated 043, 050 and 051.

  3. Added updated version of 'HCM-CoV2-043-v3 Ethanol TCF'.

  4. Added reports 34 to 55.

  5. Added 2 SARS-CoV-2 inactivation testing interim reports.

  6. Added 12 SARS-CoV-2 inactivation testing interim reports.

  7. First published.

Documents

HCM-CoV2-077-v1_DiaSorin_LIAISON_SARS-CoV-2 Ag_Inactivation_Buffer_TCF

Ref: GW-8122

PDF, 149 KB, 5 pages

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HCM-CoV2-076-v1 Mologic_COVID_19_Rapid_Antigen_Test _(Swab)_Buffer_TCF

Ref: GW-8122

PDF, 118 KB, 4 pages

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HCM-CoV2-075-v1_Hypochlorous_Acid_F_K_Holdings_TCF

Ref: GW-8122

PDF, 133 KB, 4 pages

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HCM-CoV2-074-v1_ScheBo_SARS_CoV_2_Quick_Antigen_Extraction_Buffer_TCF

Ref: GW-8122

PDF, 118 KB, 4 pages

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HCM-CoV2-073-v1_Zeesan_Saliva_RNA_Sample_Collection_Kit_buffer_TCF

Ref: GW-8122

PDF, 119 KB, 4 pages

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HCM-CoV2-072-v1_LGC_Salicovgel- TCF

Ref: GW-8122

PDF, 119 KB, 4 pages

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HCM-CoV2-071-v2_GeneMe_SAVD_Buffer_TCF

Ref: GW-8122

PDF, 131 KB, 5 pages

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HCM-CoV2-070-v1_GeneMe_FRANKD_Buffer_TCF

Ref: GW-8122

PDF, 116 KB, 4 pages

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HCM-CoV2-061-v2 Novacyt_PROmate_Sample_Preparation_Buffer _Triton_X_100_(standard)_TCF

PDF, 118 KB, 4 pages

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HCM/CoV2/068/v1 MELT V4 Buffer

Ref: PHE publications gateway number GW-1859

PDF, 212 KB, 4 pages

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HCM/CoV2/067/v1 MELT V3 Buffer

Ref: PHE publications gateway number GW-1859

PDF, 212 KB, 4 pages

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HCM/CoV2/066/v2 Veritor Extraction Reagent

Ref: PHE publications gateway number GW-1859

PDF, 216 KB, 4 pages

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HCM/CoV2/065/v1 Salicovgel-1

Ref: PHE publications gateway number GW-1859

PDF, 212 KB, 4 pages

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HCM/CoV2/064/v1 MicroLYSIS-RNA Direct to PCR Lysis Solution

Ref: PHE publications gateway number GW-1859

PDF, 213 KB, 4 pages

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HCM/CoV2/063/v1 ID NOW COVID-19 Elution Buffer

Ref: PHE publications gateway number GW-1859

PDF, 215 KB, 4 pages

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HCM/CoV2/062/v1 taco Sample Storage Solution

Ref: PHE publications gateway number GW-1859

PDF, 215 KB, 4 pages

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HCM-CoV2-061-v2 Novacyt_PROmate_Sample_Preparation_Buffer _Triton_X_100_(standard)_TCF

Ref: GW-8122

PDF, 115 KB, 4 pages

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HCM-CoV2-060-v2_Novacyt_PROmate_Sample_Preparation_Buffer_(Triton X-100 reduced)_TCF

Ref: GW-8122

PDF, 115 KB, 4 pages

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HCM/CoV2/059/v1 virusPHIX-P9

Ref: PHE publications gateway number GW-1859

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HCM/CoV2/058/v1 MELT V1

Ref: PHE publications gateway number GW-1859

PDF, 213 KB, 4 pages

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HCM/CoV2/057/v1 virusPHIX-CU

Ref: PHE publications gateway number GW-1859

PDF, 212 KB, 4 pages

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HCM/CoV2/056/v1 ESPLINE SARS-CoV-2 Sample Extraction Solution

Ref: PHE publications gateway number GW-1859

PDF, 214 KB, 4 pages

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HCM-CoV2-055-v1 VirusPHIX-LV

Ref: PHE publications gateway number GW-1725

PDF, 353 KB, 4 pages

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HCM-CoV2-054-v1 Biomonde Lysis Buffer

Ref: PHE publications gateway number GW-1725

PDF, 361 KB, 4 pages

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HCM-CoV2-053-v1 Deepblue COVID-19 Antigen Test Extraction Reagent

Ref: PHE publications gateway number GW-1725

PDF, 352 KB, 4 pages

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HCM-CoV2-052-v1 Orient Gene Coronavirus Ag Rapid Test Buffer

Ref: PHE publications gateway number GW-1725

PDF, 353 KB, 4 pages

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HCM-CoV2-051-v1 70% Acetone

Ref: PHE publications gateway number GW-1859

PDF, 242 KB, 5 pages

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HCM-CoV2-050-v1 70% Isopropanol

Ref: PHE publications gateway number GW-1859

PDF, 228 KB, 4 pages

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HCM-CoV2-049-v1 Abbott Panbio COVID-19 Rapid Test Device Buffer

PDF, 353 KB, 4 pages

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HCM-CoV2-048-v1 Innova Extraction Solution

Ref: PHE publications gateway number GW-1725

PDF, 353 KB, 4 pages

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HCM-CoV2-047-v1 Standard Q COVID-19 Ag Saliva Extraction Buffer

Ref: PHE publications gateway number GW-1725

PDF, 353 KB, 4 pages

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HCM-CoV2-046-v2 VitaPCR Buffer

Ref: PHE publications gateway number GW-1725

PDF, 371 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/045/v2 LumiraDx

Ref: PHE publications gateway number: GW-1694

PDF, 186 KB, 4 pages

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HCM-CoV2-044-v1 1% Virkon

Ref: PHE publications gateway number GW-1725

PDF, 356 KB, 4 pages

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HCM-CoV2-043-v3 Ethanol TCF

Ref: PHE publications gateway number GW-1859

PDF, 243 KB, 5 pages

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HCM-CoV2-042-v1 Zeesan Biotech Buffer 401108

Ref: PHE publications gateway number GW-1725

PDF, 356 KB, 4 pages

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HCM-CoV2-041-v1 Zeesan Biotech Buffer 401120

Ref: PHE publications gateway number GW-1725

PDF, 357 KB, 4 pages

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HCM-CoV2-040-v2 D-Biotech

Ref: PHE publications gateway number GW-1725

PDF, 376 KB, 5 pages

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HCM-CoV2-039-v2 Omnigene

Ref: PHE publications gateway number GW-1725

PDF, 356 KB, 4 pages

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HCM/CoV2/038/v4 Standard Q COVID-19 Ag Extraction Buffer

Ref: PHE publications GW-1859

PDF, 219 KB, 4 pages

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HCM-CoV2-037-v2 Arcis Buffer

Ref: PHE publications gateway number GW-1725

PDF, 381 KB, 5 pages

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HCM-CoV2-036-v3 GeneFix Buffer

Ref: PHE publications gateway number GW-1725

PDF, 355 KB, 4 pages

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HCM-CoV2-035-v3 BuccalFiX Buffer

Ref: PHE publications gateway number GW-1725

PDF, 357 KB, 4 pages

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HCM-CoV2-034-v2 virusPHIX

Ref: PHE publications gateway number GW-1725

PDF, 378 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/033/v1 EO Lysis Buffer

Ref: PHE publications gateway number: GW-1464

PDF, 95.1 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/032/v1 EO VPSS

Ref: PHE publications gateway number: GW-1464

PDF, 205 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-031-v1 PHMB

Ref: PHE publications gateway number: GW-1464

PDF, 201 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-030-v1 Copan eNAT

Ref: PHE publications gateway number: GW-1464

PDF, 208 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-029-v2 MELT Medium B

Ref: PHE publications gateway number: GW-1464

PDF, 189 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-028-v1 MELT Medium A

Ref: PHE publications gateway number: GW-1464

PDF, 190 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-027-v1 Vstrip Extraction Buffer

Ref: PHE publications gateway number: GW-1464

PDF, 190 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-026-v1 Samba SCoV Buffer

Ref: PHE publications gateway number: GW-1464

PDF, 188 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-025-v1 NP40

Ref: PHE publications gateway number: GW-1464

PDF, 190 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-024-v1 SDS

Ref: PHE publications gateway number: GW-1464

PDF, 188 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/023/v1 Triton™ X-100

Ref: PHE publications gateway number GW-1373

PDF, 324 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/022/v1 Virus Transport and Preservation Medium (Inactivated)

Ref: PHE publications gateway number GW-1373

PDF, 326 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/021/v1 NeuMoDx™ Viral Lysis Buffer

Ref: PHE publications gateway number GW-1373

PDF, 323 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-019-v3 4M GITC

Ref: PHE publications gateway number: GW-1464

PDF, 211 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/019/v2 GITC 4M Transport Medium

Ref: PHE publications gateway number GW-1373

PDF, 332 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/018/v2 AVL + ethanol TCF

Ref: PHE publications gateway number GW-1373

PDF, 324 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/017/v2 MagNA Pure 96 External Lysis Buffer

Ref: PHE publications gateway number GW-1373

PDF, 323 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/016/v2 PrimeStore Molecular Transport Medium (MTM)

Ref: PHE publications gateway number GW-1373

PDF, 325 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/015/v2 cobas® Omni LYS reagent

Ref: PHE publications gateway number GW-1373

PDF, 325 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/014/v3 GHCl 40% (w/v) Transport Medium

Ref: PHE publications gateway number GW-137

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/013/v3 GITC 2M Transport Medium

Ref: PHE publications gateway number GW-1373

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/012/v2 Buffer AVL

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-009-v3 Heat Treatment

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM/CoV/008/v3 Buffer RLT + 1% β-mercaptoethanol

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/007/v2 Aptima® Specimen Transport Medium

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/006/v3 Triton™ X-100

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/005/v3 Tween® 20 (synonym: polysorbate 20)

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/004/v3 Cobas® PCR Media

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/003/v4 Panther Fusion™ Specimen Lysis Tubes

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/002/v4 Sigma MM™

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SARS-CoV-2 inactivation testing: interim report HCM/CoV/001/v4 Nuclisens® Lysis Buffer

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Details

Public Health England (PHE) has undertaken assessments of inactivation methods against SARS-CoV-2.

Included here are a series of individual interim inactivation reports with further evaluations ongoing.

These reports will be useful for COVID-19 testing laboratories developing workflows that include an inactivation step and will aid the generation of suitable and sufficient risk assessments.

These assessments are now published by UK Health Security Agency.

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