Carcinogenic dose response: defining a point of departure and potency estimates

A guidance statement from the Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC).


Defining a point of departure and potency estimates in carcinogenic dose response

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This guidance document describes:

  • how to derive points of departure (POD) such as the Benchmark Dose (BMD) and potency estimates, such as the T25 and TD50
  • how to use these measures to estimate the relative potency of carcinogens
Published 29 September 2014