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As outlined in our original report, the ACMD recognise the indisputable harms associated with taking GBL and 1,4-BD, both of which are rapidly converted to gamma-hydroxybutyrate (GHB) when ingested. GHB (but not GBL and 1,4-BD) was controlled as a Class C drug on 1st July 2003, under the Misuse of Drugs Act 1971. Our report was initiated by concerns that users of GHB may have switched to using GBL and 1,4-BD.