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Drug interactions involving CYP2D6, genetic variants, and variability in clinical response
Over-correction of haemoglobin concentration may increase the risk of death and serious cardiovascular events in patients with chronic kidney disease; it may increase the risk of thrombosis and related complications in patients with cancer.
UK medicines regulator issues its first authorisation under Project Orbis for Osimertinib (Tagrisso), a post-surgery treatment for lung cancer.
A new paper reveals how tungsten components have now been successfully scanned with x-rays to help detect defects and accurately judge its lifespan.
The risk of foetal malformation with oral retinoids is extremely high, even when used at a low dose or for a short time during pregnancy. All oral retinoids have an associated Pregnancy Prevention Programme (PPP), which is supported by educational...
Febuxostat must be stopped immediately if hypersensitivity occurs and must not be re-started in patients who have ever developed a hypersensitivity reaction to febuxostat.
The Antivirals Taskforce will identify treatments for UK patients who have been exposed to COVID-19 to stop the infection spreading and speed up recovery time.
Patients with cancer who received recombinant human erythropoietins in clinical trials had an increased risk of tumour progression and reduced overall survival compared with study controls.
Cases of sexual dysfunction, predominantly involving erectile dysfunction and decreased libido, have been reported rarely in patients taking oral isotretinoin for severe acne.
UKAEA confirms partners to help advance STEP and the commercial viability of fusion energy.
A UK and Europe-wide review of available efficacy and safety data confirmed that reboxetine has benefit over placebo in its authorised indication.
Leading the STEP programme through the next three years as it develops a commercially viable concept design.
Cases of progressive multifocal leukoencephalopathy have been reported in patients taking dimethyl fumarate for multiple sclerosis, who all had prolonged lymphopenia.
Infusion reactions and hypersensitivity reactions have been reported commonly during treatment with Avastin.
A summary of letters sent to healthcare professionals in September 2016, including important information for professionals who specialise in epilepsy treatment regarding the withdrawal from the market of retigabine (Trobalt).
Risk of intraocular lens opacification.
Tapentadol may increase seizure risk in patients taking other medicines that lower seizure threshold, for example, antidepressants and antipsychotics. Serotonin syndrome has also been reported when tapentadol is used in combination with serotoninergic antidepressants.
Toremifene (fareston) is associated with a dose-dependent risk of QT prolongation.
EAMS scientific opinion given to Roche Products Limited in the first line treatment of adult patients with extensive-stage small cell lung cancer, in combination with carboplatin and etoposide
Patients who present with acute or worsening signs and symptoms of keratitis should be referred promptly to an ophthalmology specialist.
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