Bevacizumab (Avastin): hypersensitivity and infusion reactions

Infusion reactions and hypersensitivity reactions have been reported commonly during treatment with Avastin.

Article date: June 2010

Bevacizumab (Avastin) is a monoclonal antibody, which inhibits vascular endothelial growth factor and is authorised for the treatment of various metastatic cancers.

Healthcare professionals are advised to be aware that infusion reactions and hypersensitivity reactions have been reported commonly (≥1/100–<1/10) during treatment with Avastin. The incidence of such reactions is estimated to be up to 5% in clinical trials. Symptoms reported have included dyspnoea, flushing, rash, hypotension or hypertension, oxygen desaturation, chest pain, rigors, and nausea or vomiting. These reactions normally resolve quickly if the infusion is stopped immediately. Treatment with corticosteroids, antihistamines, oxygen, and intravenous fluids may also be administered as clinically indicated.

Further information is available in a letter for healthcare professionals sent in April 2010.

Article citation: Drug Safety Update June 2010, vol 3 issue 11: 5. 

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