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Information about when you need to submit substantial amendments to a clinical trial including changes to the trial sponsor or legal representative, Investigational medicinal product certification and importation.
Change your protocol, update your authorisation, report safety issues, submit safety updates and complete your end-of-trial study report.
Check when packaging is classified as a finished plastic packaging component, and what is meant by substantial modifications, to find out if you must register for the tax.
How to notify the MHRA of your intention to carry out a clinical investigation for medical devices.
How to tax a beneficial loan arrangement for a director or employee.
This guidance provides information on comparator products used in studies supporting abridged marketing authorisation applications
How to apply for a clinical trial including eligibility, phases, model IMPDs, costs and how to make changes to your application.
How investigators and sponsors should manage clinical trials during COVID-19
If you're an ISA manager, check how to manage additional permitted subscriptions for a surviving spouse or civil partner of a deceased investor.
Find out about sending a Stamp Duty Land Tax (SDLT) return, late filing penalties, amending a return and applying for a refund.
Sets out special provisions for Crown development for dealing with security-sensitive information in planning applications.
Find out the rules to establish the country of origin of imported and exported goods and to help identify goods which qualify for lower or no Customs Duty.
Investors and businesses may be legally required to tell the government about certain sensitive acquisitions under the National Security and Investment Act.
How to work out the VAT on building work and materials if you're a contractor, subcontractor or developer.
Find out about clearance applications and how to apply to HMRC for advance confirmation of an exempt distribution when a company purchases its own shares.
Rules for moving goods between the UK and EU under the Trade and Cooperation Agreement.
How to transfer all your charity’s assets to another charity if it merges, changes structure or closes.
This contains important actions and clarifications for institutions delivering 16 to 19 study programmes.
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