Guidance

Preparation and mixing instructions for VidPrevtyn™ Beta COVID-19 vaccine

Updated 5 April 2023

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This publication is available at https://www.gov.uk/government/publications/vidprevtyn-beta-covid-19-vaccine-instructions-for-use/preparation-and-mixing-instructions-for-vidprevtyn-beta-covid-19-vaccine

Presentation

VidPrevtyn Beta™ is supplied as 2 multi-dose vials, an antigen solution and an adjuvant emulsion that must be mixed before injection.

The antigen solution is a colourless, clear liquid and the adjuvant emulsion is a whitish to yellowish homogeneous milky liquid.

Preparation and mixing

Step 1

Place the vials at room temperature for a minimum of 15 minutes protected from light.

Step 2

Invert each vial and inspect them visually for any foreign particulate matter or discolouration. Do not use if either are present.

Do not shake.

Step 3

Remove the flip-off cap and cleanse both vial stoppers with antiseptic swabs.

Step 4

Use a sterile 21-gauge or narrower needle and sterile syringe to withdraw the entire contents from the adjuvant vial.

Step 5

Transfer the full syringe contents into the antigen vial.

Step 6

Mix the contents by inverting the vial 5 times. Do not shake.

The mixed vaccine is a whitish to yellowish homogeneous milky liquid emulsion; do not use the vaccine if the appearance is otherwise.

Step 7

Record the 6 hour discard date and time on the designated area of the vial label.

Individual doses

Drawing up individual doses:

  • the prepared vial now contains 10 doses of 0.5ml
  • an additional overfill is added to ensure that the 10 doses can be delivered
  • cleanse the vial stopper with antiseptic swabs and use a new needle (23 gauge or narrower) and a new syringe for drawing up and administration
  • withdraw 0.5ml from the vial containing the mixed vaccine
  • administer into the deltoid muscle
  • use all the doses within 6 hours of mixing
  • do not pool residual volumes from several vials

Administration

A single dose should be administered in the densest part of the deltoid muscle of the upper arm.

Storage

Mixed product can be kept at room temperature whilst in use at a clinic session. In other settings, such as domiciliary vaccination, the product may be returned to a vaccine fridge or cool box between each vaccination.

All 10 doses should be used as soon as practically possible and any remaining unused doses discarded after 6 hours.

Order or download print copies

A PDF poster version of these instructions, which includes images, is available to download. Print copies are available and free to pre-order from Health Publications.

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