Research and analysis

Antenatal and newborn screening KPI data: Q4 summary factsheets (1 January to 31 March 2025)

Published 14 August 2025

Applies to England

© Crown copyright 2025

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This publication is available at https://www.gov.uk/government/publications/quarter-4-kpi-report-1-january-to-31-march-2025/antenatal-and-newborn-screening-kpi-data-q4-summary-factsheets-1-january-to-31-march-2025

This report should be read in conjunction with the full KPI data tables published each quarter.

1. Fetal anomaly screening

1.1 KPI FA2: coverage: fetal anomaly ultrasound

National performance of FA2 (see standard FASP-S02) in quarter 3 2024 to 2025 was 98.9%. FA2 is collected 6 months (2 quarters) in arrears.

Quarter 3 performance

Reporting period Numerator Denominator Performance %
Quarter 3 2024 to 2025 134,904 136,420 98.9%
Region Performance %
East of England 99.2%
London 98.3%
Midlands 99.1%
North East and Yorkshire 99.0%
North West 98.9%
South East 99.0%
South West 99.0%
England 98.9%

1.2 KPI FA3

There is no intention to publish FA3 (see standard FASP-S01) by individual maternity service.

1.3 KPI FA4: combined samples

FA4 (see standard FASP-SO6) was introduced in 2020 to 2021. New KPIs are not published in the first year of data collection. This time is used to improve the data quality and completeness, by revising the definition, adding clarity and / or setting thresholds as required.

In quarter 4 2024 to 2025, national performance of FA4 for inadequate combined samples was 3.8%. FA4 is a KPI where a lower performance is better.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 4,384 114,610 3.8%
Region Performance %
East of England 2.9%
London 1.9%
Midlands 4.3%
North East and Yorkshire 6.5%
North West 4.3%
South East 4.8%
South West 2.2%
England 3.8%

1.4 KPI FA4: quadruple samples

FA4 (see standard FASP-S06) was introduced in 2020 to 2021. New KPIs are not published in the first year of data collection. This time is used to improve the data quality and completeness, by revising the definition, adding clarity and / or setting thresholds as required.

In quarter 4 2024 to 2025, national performance of FA4 for inadequate quadruple samples was 7.7%. FA4 is a KPI where a lower performance is better.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 985 12,792 7.7%
Region Performance %
East of England 4.4%
London 3.2%
Midlands 6.8%
North East and Yorkshire 16.8%
North West 4.7%
South East 12.4%
South West 12.7%
England 7.7%

2. Infectious diseases in pregnancy screening

2.1 KPI ID1: HIV coverage

National performance of ID1 (see standard IDPS-S01) in quarter 4 2024 to 2025 was 99.8%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 161,989 162,288 99.8%
Region Performance %
East of England 99.8%
London 99.9%
Midlands 99.8%
North East and Yorkshire 99.8%
North West 99.8%
South East 99.8%
South West 99.6%
England 99.8%

2.2 KPI ID2: diagnosis/intervention: timely assessment of women with hepatitis B

National performance of ID2 (see standard IDPS-S06) in quarter 4 2024 to 2025 was 72.0%. The submission of data for ID2 has changed in 2023 to 2024 from maternity service self-reporting to the Integrated Screening Outcomes Surveillance Service (ISOSS) to improve consistency and accuracy of data returns. This has led to an expected reduction in performance as a result of more accurate data, and does not reflect a change in practice for screening providers.

In April 2023 the acceptable threshold changed from greater than or equal to 70% to greater than or equal to 75%. Due to the way the chart is currently produced, the acceptable threshold is presented as greater than or equal to 75% for all time periods.

ID2 is a small number KPI, therefore the data should be interpreted with caution.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 95 132 72.0%
Region Performance %
East of England 66.7%
London 70.3%
Midlands 75.9%
North East and Yorkshire 63.6%
North West 77.8%
South East 100.0%
South West 63.6%
England 72.0%

2.3 KPI ID3: coverage: hepatitis B

National performance of ID3 (see standard IDPS-S02) in quarter 4 2024 to 2025 was 99.8%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 161,985 162,284 99.8%
Region Performance %
East of England 99.8%
London 99.9%
Midlands 99.8%
North East and Yorkshire 99.8%
North West 99.8%
South East 99.8%
South West 99.6%
England 99.8%

2.4 KPI ID4: coverage: syphilis

National performance of ID4 (see standard IDPS-S03) in quarter 4 2024 to 2025 was 99.8%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 161,977 162,275 99.8%
Region Performance %
East of England 99.8%
London 99.9%
Midlands 99.8%
North East and Yorkshire 99.8%
North West 99.8%
South East 99.8%
South West 99.6%
England 99.8%

3. Sickle cell and thalassaemia screening

3.1 KPI ST1: coverage: antenatal screening

National performance of ST1 (see standard SCT-S01) in quarter 4 2024 to 2025 was 99.8%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 161,932 162,267 99.8%
Region Performance %
East of England 99.8%
London 99.9%
Midlands 99.7%
North East and Yorkshire 99.8%
North West 99.8%
South East 99.8%
South West 99.6%
England 99.8%

3.2 KPI ST2: test: timeliness of antenatal screening

National performance of ST2 (see standard SCT-S02) in quarter 4 2024 to 2025 was 63.5%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 104,268 164,245 63.5%
Region Performance %
East of England 67.1%
London 57.5%
Midlands 55.7%
North East and Yorkshire 74.2%
North West 59.1%
South East 68.3%
South West 70.2%
England 63.5%

3.3 KPI ST3: test: completion of family origin questionnaire (FOQ)

National performance of ST3 (see standard SCT-S03) in quarter 4 2024 to 2025 was 97.8%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 161,825 165,475 97.8%
Region Performance %
East of England 98.5%
London 97.9%
Midlands 96.2%
North East and Yorkshire 98.3%
North West 97.5%
South East 98.4%
South West 98.7%
England 97.8%

3.4 KPI ST4a: referral: timely offer of prenatal diagnosis (PND) to women at risk of having an infant with sickle cell disease or thalassaemia

National performance of ST4a (see standard SCT-S05) in quarter 4 2024 to 2025 was 54.5%. Thresholds have not yet been set for this KPI.

ST4a is a small number KPI, therefore the data should be interpreted with caution.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 301 552 54.5%
Region Performance %
East of England 71.2%
London 53.2%
Midlands 45.5%
North East and Yorkshire 45.7%
North West 52.4%
South East 62.8%
South West 60.0%
England 54.5%

3.5 KPI ST4b: referral: timely offer of prenatal diagnosis (PND) to couples at risk of having an infant with sickle cell disease or thalassaemia

National performance of ST4b (see standard SCT-S05) in quarter 4 2024 to 2025 was 67.5%. Thresholds have not yet been set for this KPI.

ST4b is a small number KPI, therefore the data should be interpreted with caution.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 245 363 67.5%
Region Performance %
East of England 87.1%
London 73.6%
Midlands 59.7%
North East and Yorkshire 79.5%
North West 40.4%
South East 67.3%
South West 78.6%
England 67.5%

4. Newborn blood spot screening

4.1 KPI NB1: coverage of Sub ICB responsibility at birth

National performance of NB1 (see standard NBS-S01a) in quarter 4 2024 to 2025 was 97.7%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 127,433 130,459 97.7%
Region Performance %
East of England 99.6%
London 98.0%
Midlands 97.6%
North East and Yorkshire 97.0%
North West 96.5%
South East 97.3%
South West 98.2%
England 97.7%

4.2 KPI NB2: test: quality of the blood spot sample

National performance of NB2 (see standard NBS-S06) in quarter 4 2024 to 2025 was 2.7%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 3,610 134,412 2.7%
Region Performance %
East of England 1.9%
London 2.7%
Midlands 2.6%
North East and Yorkshire 2.8%
North West 2.9%
South East 3.1%
South West 2.5%
England 2.7%

4.3 KPI NB4: coverage of movers in

National performance of NB4 (see standard NBS-S01b) in quarter 4 2024 to 2025 was 83.3%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 10,108 12,135 83.3%
Region Performance %
East of England 87.2%
London 73.8%
Midlands 83.0%
North East and Yorkshire 89.3%
North West 89.3%
South East 84.1%
South West 83.8%
England 83.3%

5. Newborn hearing screening

5.1 KPI NH1: coverage

National performance of NH1 (see standard NHSP-S01) in quarter 4 2024 to 2025 was 98.6%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 133,045 134,892 98.6%
Region Performance %
East of England 98.8%
London 99.0%
Midlands 99.3%
North East and Yorkshire 98.9%
North West 95.5%
South East 99.4%
South West 99.2%
England 98.6%

5.2 KPI NH2: diagnosis/intervention – time from screening outcome to attendance at an audiological assessment appointment

National performance of NH2 (see standard NHSP-S05) in quarter 4 2024 to 2025 was 91.0%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 2,204 2,422 91.0%
Region Performance %
East of England 89.1%
London 91.8%
Midlands 89.7%
North East and Yorkshire 89.1%
North West 90.4%
South East 97.7%
South West 93.9%
England 91.0%

6. Newborn and infant physical examination screening

6.1 KPI NP1: coverage

National performance of NP1 (see standard NIPE-S01) in quarter 4 2024 to 2025 was 96.5%.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 130,565 135,283 96.5%
Region Performance %
East of England 96.8%
London 96.7%
Midlands 96.7%
North East and Yorkshire 96.2%
North West 96.0%
South East 96.2%
South West 97.3%
England 96.5%

6.2 KPI NP4: diagnosis/intervention – timeliness of hip clinical assessment or discharge

NP4 (see standard NIPE-S04) was introduced in 2024 to 2025.

In quarter 4 2024 to 2025, national performance of NP4 was 79.7%. As this quarter is the first time data is available for this KPI there is no chart.

Quarter 4 performance

Reporting period Numerator Denominator Performance %
Quarter 4 2024 to 2025 9,528 11,961 79.7%
Region Performance %
East of England 84.5%
London 79.5%
Midlands 83.7%
North East and Yorkshire 78.3%
North West 77.7%
South East 77.5%
South West 74.8%
England 79.7%
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