Research and analysis

Biological dosimetry: statistical methods

This report (HPA-RPD-011) reviews statistical methods for biological dosimetry by analysis of chromosomal aberrations in blood lymphocytes.

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Statistical methods most commonly employed at the Health Protection Agency for purposes of biological dosimetry by analysis of chromosomal aberrations in blood lymphocytes are reviewed and discussed together with worked examples illustrating practical aspects of the techniques. A novel method of computation of dose and the corresponding 95% limits, taking into account both the Poisson derived uncertainties in induced aberration yield as well as uncertainties associated with the calibration curve, is presented.