Research and analysis

Biological dosimetry: statistical methods

This report (HPA-RPD-011) reviews statistical methods for biological dosimetry by analysis of chromosomal aberrations in blood lymphocytes.

Document

HPA-RPD-011: statistical methods for biological dosimetry

This file may not be suitable for users of assistive technology. Request an accessible format.

If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email publications@phe.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

Details

Statistical methods most commonly employed at the Health Protection Agency for purposes of biological dosimetry by analysis of chromosomal aberrations in blood lymphocytes are reviewed and discussed together with worked examples illustrating practical aspects of the techniques. A novel method of computation of dose and the corresponding 95% limits, taking into account both the Poisson derived uncertainties in induced aberration yield as well as uncertainties associated with the calibration curve, is presented.

Published 1 December 2005