This will be his first official visit to the United States since he took office in May and is expected to deepen UK-US cooperation on a range of global challenges including the economy and Afghanistan.
The Prime Minister and President will meet at the White House on Tuesday morning. This meeting will follow up a substantive discussion between the two leaders last month at the G20 Summit in Canada in which they agreed a common approach to securing solid, sustainable growth in the world economy and that a strong political strategy is needed in Afghanistan to complement the military campaign.
Following his meeting with the President on Tuesday, Mr Cameron will visit Capitol Hill for discussions with senior senators and members of Congress from both parties.
On Wednesday morning, the Prime Minister will honour the service and sacrifice of members of the US armed forces by laying a wreath at the Tomb of the Unknowns at Arlington National Cemetery. Mr Cameron will then visit the Pentagon for a briefing on the current situation in Afghanistan with senior US military officials.
The Prime Minister travels to New York City on Wednesday afternoon to promote British business.