Work to improve sections of the motorway – which includes replacement of road markings and studs – will begin on Monday, 6 July.
To make the most of these closures between 8pm and 6am general maintenance will also be carried out.
Highways England project manager, Daniel Edwards, said:
This resurfacing work will replace the worn out carriageway making the road safer and smoother to travel along. Additionally we will be white lining this section of the A1(M) southbound between junctions 45 and 42 which will help to improve safety.
We realise this will cause some disruption to motorists as we will have a temporary 50mph speed limit on the link road connecting the A64 westbound carriageway with the A1(M) southbound carriageway at Bramham crossroads, and the A1(M) southbound carriageway from Paradise Farm overbridge to Hook Moor Interchange whilst we carry out the work.
To minimise disruption to drivers we will carry out general maintenance at the same time. We would ask drivers to drive carefully and follow the clearly signed diversion routes for the duration of this work.
The southbound A1(M) from junction 45 (Boston Spa) to junction 44 (Bramham crossroads) will be closed from 6 to 28 July.
The dedicated link road connecting the A64 westbound carriageway with the southbound A1(M) carriageway at Bramham crossroads (A1(M) junction 44) will be closed between 28 July and 4 September.
The southbound A1(M) carriageway from junction 43 at Hook Moor Interchange to junction 42 at Selby Fork will be closed from 18 August to 4 September.
The M1 southbound carriageway from junction 48 at Hook Moor Interchange to junction 47 at Parlington and the southbound M1 exit slip road at junction 47 will be closed between 22 September and 26 September.
The southbound A1(M) exit and entry slip roads and northbound entry slip road at junction 44 will be closed from 28 September to 10 October.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.