Contractors for Highways England need to close the westbound carriageway from 8pm on Monday to 6am the following day and again overnight on Monday 28 September to allow for piling work.
The A180 westbound carriageway between Stallingbrough and Brocklesby will be closed overnight between 8pm on Friday 25 September and 6am the following day for the installation of safety barriers.
Drivers will be able to follow clearly signed diversion routes.
Highways England project manager Ben Ridgeon said:
We are carrying out this improvement work at night when traffic levels are at their lowest to minimise disruption to road users.
Once this scheme has been completed, traffic congestion will be reduced, journey times will become more reliable, and safety will be improved for road users and the local community. There will also be better access to the Port of Immingham and the surrounding area.
The £88.4 million project began in March and aims to provide better access to the port and the surrounding area, stimulating growth and unlocking economic benefits. It is due to be completed in summer 2016.
The Port of Immingham is the UK’s largest port by tonnage and handles up to 55 million tonnes of goods every year, including nearly 20 million tonnes of oil and 10 million tonnes of coal.
More details on the scheme, including a computer-generated video showing how the upgraded road will look, are available on the scheme page.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.