Skip to main content

Drug Safety Update

From:
Medicines and Healthcare products Regulatory Agency
Skip to results
  • Tapentadol (Palexia): risk of seizures and reports of serotonin syndrome when co-administered with other medicines

    Tapentadol may increase seizure risk in patients taking other medicines that lower seizure threshold, for example, antidepressants and antipsychotics. Serotonin syndrome has also been reported when tapentadol is used in combination with serotoninergic antidepressants.

    • Therapeutic area: Neurology and 3 others
    • Published:
  • Opioids: risk of dependence and addiction

    New recommendations following a review of the risks of dependence and addiction associated with prolonged use of opioid medicines (opioids) for non-cancer pain. Before prescribing opioids, discuss with the patient the risks …

    • Therapeutic area: Pain management and palliation
    • Published: