Drug Safety Update

…Weigh the benefit of erythromycin therapy in infants against the potential risk of infantile hypertrophic pyloric stenosis.…

• Therapeutic area: Infectious disease and 1 others
• Published: 17 December 2020

…Erythromycin has been associated with events secondary to QT interval prolongation such as cardiac arrest and ventricular fibrillation.…

• Therapeutic area: Haematology and oncology and 1 others
• Published: 17 December 2020

Carefully consider the benefits and risks before prescribing systemic azithromycin or other systemic macrolide antibiotics (erythromycin or clarithromycin) to patients being treated with hydroxychloroquine or chloroquine.…

• Therapeutic area: Dermatology and 3 others
• Published: 15 February 2022

Indication restricted to second-line treatment and contraindicated with some cardiovascular conditions and medicines Furthermore, cilostazol is now contraindicated in patients with any of the following: Unstable ang…

• Therapeutic area: Cardiovascular disease and lipidology
• Published: 11 December 2014

Detailed recommendations for dose restrictions when used with some other drugs as interactions may increase the risk of adverse effects, or reduce the effectiveness of statin treatment.

• Therapeutic area: Cardiovascular disease and lipidology
• Published: 11 December 2014

Updated contraindications and maximum dose recommendations when taken with a number of other medicines.

• Therapeutic area: Cardiovascular disease and lipidology and 1 others
• Published: 11 December 2014

New maximum daily dose restrictions (including in elderly patients), contraindications, and warnings.

• Therapeutic area: Psychiatry
• Published: 11 December 2014

MHRA has received reports of unintentional overdose of fentanyl due to dosing errors, accidental exposure, and exposure of the patch to a heat source.

• Therapeutic area: Pain management and palliation
• Published: 11 December 2014