Accredited official statistics

Gram-negative, MRSA, MSSA bacteraemia and C. difficile infections, from October 2024 to October 2025: monthly data trends

Updated 3 December 2025

This bulletin provides a brief overview of all cases reported through the national mandatory surveillance of bacteraemia and C. difficile infections (CDI) for the latest month.

The UKHSA data dashboard presents supplementary monthly data visualisations of trends covering the latest 13-month period, with options to filter data by location. For longer term trends, detailed epidemiological commentaries covering the period from the beginning of surveillance onward are presented within the quarterly and annual reports, within this statistical series.

Main points

Escherichia coli (E. coli) bacteraemia

In October 2025:

• overall, 3,829 E. coli bacteraemia cases were reported, an increase of 1.4% when compared with the same month of the previous year (n=3,775)

• hospital-onset, healthcare-associated (HOHA) E. coli bacteraemia cases decreased by 5.9% (n=687) when compared with the same month of the previous year (n=730)

• community-onset, healthcare-associated (COHA) E. coli bacteraemia cases increased by 7.1% (n=592) when compared with the same month of the previous year (n=553)

• community-onset, community-associated (COCA) E. coli bacteraemia cases increased by 2.2% (n=2,546) when compared with the same month of the previous year (n=2,490)

Klebsiella species (spp.) bacteraemia

In October 2025:

• overall, 1,209 Klebsiella spp. bacteraemia cases were reported, an increase of 1.9% when compared with the same month of the previous year (n=1,186)

• hospital-onset, healthcare-associated (HOHA) Klebsiella spp. bacteraemia cases decreased by 0.3% (n=372) when compared with the same month of the previous year (n=373)

• community-onset, healthcare-associated (COHA) Klebsiella spp. bacteraemia cases increased by 12.4% (n=199) when compared with the same month of the previous year (n=177)

• community-onset, community-associated (COCA) Klebsiella spp. bacteraemia cases increased by 0.2% (n=637) when compared with the same month of the previous year (n=636)

Pseudomonas aeruginosa (P. aeruginosa) bacteraemia

In October 2025: 

• overall, 423 P. aeruginosa bacteraemia cases were reported, a decrease of 5.6% when compared with the same month of the previous year (n=448)

• hospital-onset, healthcare-associated (HOHA) P. aeruginosa bacteraemia cases decreased by 22.2% (n=144) when compared with the same month of the previous year (n=185)

• community-onset, healthcare-associated (COHA) P. aeruginosa bacteraemia cases increased by 21.3% (n=91) when compared with the same month of the previous year (n=75)

• community-onset, community-associated (COCA) P. aeruginosa bacteraemia cases were (n=188) which were same to the month of the previous year (n=188)

Meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia

In October 2025: 

• overall, 88 MRSA bacteraemia cases were reported, an increase of 8.6% when compared with the same month of the previous year (n=81)

• hospital-onset, healthcare-associated (HOHA) MRSA bacteraemia cases decreased by 12.5% (n=28) when compared with the same month of the previous year (n=32)

• community-onset, healthcare-associated (COHA) MRSA bacteraemia cases increased by 50% (n=12) when compared with the same month of the previous year (n=8)

• community-onset, community-associated (COCA) MRSA bacteraemia cases increased by 17.1% (n=48) when compared with the same month of the previous year (n=41)

Meticillin-susceptible Staphylococcus aureus (MSSA) bacteraemia

In October 2025: 

• overall, 1,231 MSSA bacteraemia cases were reported, an increase of 0.6% when compared with the same month of the previous year (n=1,224)

• hospital-onset, healthcare-associated (HOHA) MSSA bacteraemia cases decreased by 1.2% (n=339) when compared with the same month of the previous year (n=343)

• community-onset, healthcare-associated (COHA) MSSA bacteraemia cases decreased by 4.4% (n=152) when compared with the same month of the previous year (n=159)

• community-onset, community-associated (COCA) MSSA bacteraemia cases increased by 2.8% (n=740) when compared with the same month of the previous year (n=720)

C. difficile infections (CDI)

In October 2025: 

• overall, 1,557 CDI cases were reported, a decrease of 13.9% when compared with the same month of the previous year (n=1,809)

• hospital-onset, healthcare-associated (HOHA) CDI cases decreased by 22.8% (n=648) when compared with the same month of the previous year (n=839)

• community-onset, healthcare-associated (COHA) CDI cases decreased by 1.3% (n=297) when compared with the same month of the previous year (n=301)

• community-onset, community-associated (COCA) CDI cases decreased by 10.6% (n=437) when compared with the same month of the previous year (n=489)

• community-onset, indeterminate-association (COIA) CDI cases decreased by 2.2% (n=175) when compared with the same month of the previous year (n=179)

Data sources and methodology

For further information on our data sources and the methodology used to analyse data in this report, please refer to our QMI report. Due to month-to-month fluctuations and potential shifts in seasonal patterns across the year, comparisons between individual months to the corresponding month in previous year should be interpreted with caution.

Background information

This publication forms part of the range of accredited Official Statistics outputs routinely published by UKHSA which include monthly and annual reports on the mandatory surveillance of MRSA, MSSA and E. coli, Klebsiella spp. and P. aeruginosa bacteraemia and CDI.

Data for this report was extracted from UKHSA’s HCAI DCS on 25 November 2025.

Further information and contact details

Feedback and contact information

For any enquiries or feedback on this report, or to request copies of this report in PDF format, please contact mandatory.surveillance@ukhsa.gov.uk

Accredited official statistics

Our statistical practice is regulated by the Office for Statistics Regulation (OSR). OSR sets the standards of trustworthiness, quality and value in the Code of Practice for Statistics that all producers of Official Statistics should adhere to. You are welcome to contact us directly by mandatory.surveillance@ukhsa.gov.uk with any comments about how we meet these standards. Alternatively, you can contact OSR by emailing regulation@statistics.gov.uk  or via the OSR website.

These official statistics were independently reviewed by the OSR in May 2022. They comply with the standards of trustworthiness, quality and value in the Code of Practice for Statistics and should be labelled ‘accredited official statistics’. Accredited official statistics are called National Statistics in the Statistics and Registration Service Act 2007. Further explanation of accredited official statistics can be found on the Office for Statistics Regulation website.