Accredited official statistics

Gram-negative, MRSA, MSSA bacteraemia and C. difficile infections, from August 2024 to August 2025: monthly data trends

Updated 1 October 2025

This bulletin provides a brief overview of all cases reported through the national mandatory surveillance of bacteraemia and C. difficile infections (CDI) for the latest month.

The UK Health Security Agency (UKHSA) data dashboard presents supplementary monthly data visualisations of trends covering the latest 13-month period, with options to filter data by location. For longer term trends, detailed epidemiological commentaries covering the period from the beginning of surveillance onward are presented within the quarterly and annual reports, within this statistical series.

Main points

Escherichia coli (E. coli) bacteraemia

In August 2025:

• overall, 4,167 E. coli bacteraemia cases were reported, an increase of 4.0% when compared with the same month of the previous year (n=4,006)
• hospital-onset healthcare-associated (HOHA) E. coli bacteraemia cases increased by 0.5% (n=739) when compared with the same month of the previous year (n=735)
• community-onset healthcare-associated (COHA) E. coli bacteraemia cases increased by 5.3% (n=598) when compared with the same month of the previous year (n=568)
• community-onset community-associated (COCA) E. coli bacteraemia cases increased by 4.9% (n=2,829) when compared with the same month of the previous year (n=2,698)

Klebsiella species (spp.) bacteraemia

In August 2025:

• overall, 1,272 Klebsiella spp. bacteraemia cases were reported, an increase of 4.5% when compared with the same month of the previous year (n=1,217)
• HOHA Klebsiella spp. bacteraemia cases decreased by 3.7% (n=365) when compared with the same month of the previous year (n=379)
• COHA Klebsiella spp. bacteraemia cases increased by 10.8% (n=185) when compared with the same month of the previous year (n=167)
• COCA Klebsiella spp. bacteraemia cases increased by 7.6% (n=719) when compared with the same month of the previous year (n=668)

Pseudomonas aeruginosa (P. aeruginosa) bacteraemia

In August 2025:

• overall, 434 P. aeruginosa bacteraemia cases were reported, an increase of 0.7% when compared with the same month of the previous year (n=431)
• HOHA P. aeruginosa bacteraemia cases increased by 1.3% (n=160) when compared with the same month of the previous year (n=158)
• COHA P. aeruginosa bacteraemia cases increased by 9.0% (n=85) when compared with the same month of the previous year (n=78)
• COCA P. aeruginosa bacteraemia cases decreased by 3.1% (n=189) when compared with the same month of the previous year (n=195)

Meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia

In August 2025:

• overall, 81 MRSA bacteraemia cases were reported, an increase of 8.0% when compared with the same month of the previous year (n=75)
• HOHA MRSA bacteraemia cases increased by 3.8% (n=27) when compared with the same month of the previous year (n=26)
• COHA MRSA bacteraemia cases decreased by 9.1% (n=10) when compared with the same month of the previous year (n=11)
• COCA MRSA bacteraemia cases increased by 15.8% (n=44) when compared with the same month of the previous year (n=38)

Meticillin-susceptible Staphylococcus aureus (MSSA) bacteraemia

In August 2025:

• overall, 1,155 MSSA bacteraemia cases were reported, a decrease of 1.1% when compared with the same month of the previous year (n=1,168)
• HOHA MSSA bacteraemia cases decreased by 11.8% (n=307) when compared with the same month of the previous year (n=348)
• COHA MSSA bacteraemia cases increased by 16.4% (n=163) when compared with the same month of the previous year (n=140)
• COCA MSSA bacteraemia cases increased by 1.0% (n=684) when compared with the same month of the previous year (n=677)

Clostridioides difficile infection (CDI)

In August 2025:

• overall, 1616 CDI cases were reported, a decrease of 12.3% when compared with the same month of the previous year (n=1,842)
• HOHA CDI cases decreased by 14.3% (n=675) when compared with the same month of the previous year (n=788)
• COHA CDI cases decreased by 8.0% (n=297) when compared with the same month of the previous year (n=323)
• COCA CDI cases decreased by 12.7% (n=474) when compared with the same month of the previous year (n=543)
• community-onset indeterminate-association (COIA) CDI cases decreased by 9.1% (n=170) when compared with the same month of the previous year (n=187)

Data sources and methodology

For further information on our data sources and the methodology used to analyse data in this report, please refer to our QMI report.

Due to month-to-month fluctuations and potential shifts in seasonal patterns across the year, comparisons between individual months and the corresponding months in previous years should be interpreted with caution.

Background information

This publication forms part of the range of accredited Official Statistics outputs routinely published by UKHSA, which include monthly and annual reports on the mandatory surveillance of MRSA, MSSA, E. coli, Klebsiella spp., P. aeruginosa bacteraemia and CDI.

Data for this report was extracted from UKHSA’s healthcare-associated infections (HCAI) Data Capture System (DCS) on 16 September 2025.

Further information and contact details

Feedback and contact information

For any enquiries or feedback on this report, or to request copies of this report in PDF format, please contact mandatory.surveillance@ukhsa.gov.uk

Accredited official statistics

Our statistical practice is regulated by the Office for Statistics Regulation (OSR). OSR sets the standards of trustworthiness, quality and value in the Code of Practice for Statistics that all producers of Official Statistics should adhere to. You are welcome to contact us directly by mandatory.surveillance@ukhsa.gov.uk with any comments about how we meet these standards. Alternatively, you can contact OSR by emailing regulation@statistics.gov.uk  or via the OSR website.

These official statistics were independently reviewed by the OSR in May 2022. They comply with the standards of trustworthiness, quality and value in the Code of Practice for Statistics and should be labelled ‘accredited official statistics’. Accredited official statistics are called National Statistics in the Statistics and Registration Service Act 2007. Further explanation of accredited official statistics can be found on the Office for Statistics Regulation website.