Research and analysis
NOIDs causative agents: week 31 (week ending 6 August 2023)
Updated 2 January 2024
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Laboratories in England have a statutory duty to notify the UK Health Security Agency (UKHSA) of the identification of the following causative agents:
- Bacillus anthracis
- Bacillus cereus
- Bordetella pertussis
- Borrelia spp
- Brucella spp
- Burkholderia mallei
- Burkholderia pseudomallei
- Campylobacter spp
- Carbapenemase-producing Gram-negative bacteria
- Chikungunya virus
- Chlamydophila psittaci
- Clostridium botulinum
- Clostridium perfringens
- Clostridium tetani
- Corynebacterium diphtheriae
- Corynebacterium ulcerans
- Coxiella burnetii
- Crimean-Congo haemorrhagic fever virus
- Cryptosporidium spp
- Dengue virus
- Ebola virus
- Entamoeba histolytica
- Escherichia coli O 157
- Francisella tularensis
- Giardia lamblia
- Guanarito virus
- Haemophilus influenzae (invasive)
- Hanta virus
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Hepatitis D
- Hepatitis E
- Influenza virus
- Junin virus
- Kyasanur Forest disease virus
- Lassa virus
- Legionella spp
- Leptospira interrogans
- Listeria monocytogenes
- Machupo virus
- Marburg virus
- Measles virus
- Mpox (monkeypox) virus
- Mumps virus
- Mycobacterium tuberculosis complex
- Neisseria meningitidis
- Omsk haemorrhagic fever virus
- Plasmodium falciparum
- Plasmodium knowlesi
- Plasmodium malariae
- Plasmodium ovale
- Plasmodium vivax
- Polio virus
- Rabies virus
- Rickettsia spp
- Rift Valley fever virus
- Rubella virus
- Sabia virus
- Salmonella spp
- SARS coronavirus
- Shigella spp
- Streptococcus group A (invasive)
- Streptococcus pneumoniae (invasive)
- Varicella zoster virus
- Variola virus
- Vibrio cholerae
- West Nile virus
- Yellow fever virus
- Yersinia pestis
Statutory notifications of causative agents, grouped by root organism
Totals for the current week compared to the previous 5.
| Week notification received | 2023/26 | 2023/27 | 2023/28 | 2023/29 | 2023/30 | 2023/31 |
|---|---|---|---|---|---|---|
| Arboviruses | ||||||
| West Nile virus | 1 | - | - | - | - | - |
| Bacillus | ||||||
| Bacillus cereus | 19 | 30 | 35 | 27 | 15 | 31 |
| Bordetella | ||||||
| Bordetella pertussis | 4 | 5 | 9 | 19 | 10 | 3 |
| Borrelia | ||||||
| Borrelia burgdorferi | 28 | 28 | 29 | 38 | 37 | 59 |
| Borrelia sp | 4 | 6 | 6 | 2 | 4 | 10 |
| Borrelia tillae | 2 | 1 | 1 | 1 | - | 1 |
| Brucella | ||||||
| Brucella sp | - | - | - | - | 1 | - |
| Campylobacter | ||||||
| Campylobacter coli | 47 | 43 | 46 | 47 | 30 | 29 |
| Campylobacter jejuni | 342 | 337 | 366 | 304 | 278 | 219 |
| Campylobacter lari | - | 1 | 1 | 2 | 1 | - |
| Campylobacter other named | 1 | 1 | - | - | 2 | 3 |
| Campylobacter sp | 1,415 | 1,333 | 1,249 | 1,100 | 1,119 | 1,218 |
| Campylobacter upsaliensis | 1 | 1 | 1 | - | 2 | - |
| Campylobacter ureolyticus (bacteroides corrodens) | - | 1 | - | 1 | - | 1 |
| Chikungunya virus | ||||||
| Chikungunya virus | 2 | - | 4 | 3 | - | 1 |
| Clostridium | ||||||
| Clostridium perfringens | 53 | 43 | 24 | 24 | 28 | 36 |
| Coronavirus | ||||||
| Coronavirus | 8 | 14 | 5 | 7 | 10 | 12 |
| SARS-CoV-2 antibody indeterminate | 60 | 88 | 61 | 69 | 124 | 91 |
| SARS-CoV-2 antibody void | 4 | 4 | 2 | 4 | 6 | 6 |
| SARS-CoV-2 coronavirus (COVID-19) | 1,871 | 2,255 | 2,795 | 3,222 | 4,296 | 5,421 |
| SARS-CoV-2 coronavirus (COVID-19) indeterminate | 28 | 34 | 24 | 21 | 24 | 33 |
| SARS-CoV-2 IgG antibody negative | 50 | 46 | 56 | 53 | 56 | 45 |
| SARS-CoV-2 IgG antibody positive | 127 | 133 | 144 | 169 | 154 | 143 |
| SARS-CoV-2 total antibody negative | 24 | 44 | 60 | 65 | 38 | 64 |
| SARS-CoV-2 total antibody positive | 126 | 117 | 155 | 125 | 93 | 150 |
| Corynebacterium | ||||||
| Corynebacterium diphtheriae | - | 4 | 1 | 1 | 4 | 2 |
| Corynebacterium ulcerans | - | 2 | 1 | - | - | - |
| Cryptosporidium | ||||||
| Cryptosporidium cuniculus | - | - | 1 | - | - | - |
| Cryptosporidium felis | 1 | - | 1 | - | - | 1 |
| Cryptosporidium hominis | 8 | 13 | 19 | 7 | 17 | 2 |
| Cryptosporidium meleagridis | - | 1 | 1 | 1 | 1 | - |
| Cryptosporidium parvum | 33 | 23 | 31 | 13 | 28 | 12 |
| Cryptosporidium sp | 9 | 31 | 28 | 24 | 32 | 62 |
| Cryptosporidium ubiquitum | - | - | - | - | 1 | - |
| Entamoeba | ||||||
| Entamoeba histolytica | 1 | 2 | 2 | - | 1 | 2 |
| Escherichia | ||||||
| Escherichia coli O 157 | 18 | 20 | 16 | 13 | 17 | 10 |
| Flaviviruses | ||||||
| Dengue virus | 4 | 2 | 5 | 1 | 3 | 9 |
| Haemophilus | ||||||
| Haemophilus influenzae | 74 | 66 | 60 | 43 | 57 | 45 |
| Hepatitis viruses | ||||||
| Hepatitis A | 10 | 13 | 11 | 4 | 10 | 10 |
| Hepatitis B | 331 | 236 | 295 | 293 | 247 | 230 |
| Hepatitis C | 433 | 443 | 362 | 384 | 325 | 410 |
| Hepatitis D | 7 | 5 | 4 | 5 | 5 | 1 |
| Hepatitis E | 47 | 36 | 32 | 38 | 31 | 34 |
| Influenza virus | ||||||
| Influenza A | 25 | 57 | 59 | 52 | 56 | 61 |
| Influenza B | 15 | 15 | 22 | 16 | 17 | 12 |
| Influenza indeterminate | - | - | 52 | - | - | - |
| Influenza ungrouped | 1 | - | 1 | 1 | - | 6 |
| Legionella | ||||||
| Legionella longbeachae | - | 1 | - | 3 | - | - |
| Legionella other named | - | - | - | - | - | 1 |
| Legionella pneumophila | 10 | 6 | 8 | 13 | 14 | 12 |
| Legionella sp | 3 | 3 | 4 | 8 | 10 | 8 |
| Listeria | ||||||
| Listeria monocytogenes | 5 | 8 | 3 | 4 | 2 | 9 |
| Mycobacterium | ||||||
| Mycobacterium tuberculosis | 90 | 96 | 76 | 71 | 75 | 68 |
| Neisseria | ||||||
| Neisseria meningitidis | 12 | 20 | 16 | 16 | 22 | 15 |
| Orthopoxvirus | ||||||
| Mpox virus | 1 | 3 | 3 | 2 | 3 | 4 |
| Paramyxoviruses | ||||||
| Measles virus | 7 | 3 | 4 | 10 | 4 | 2 |
| Mumps virus | 2 | 6 | 5 | 3 | 4 | 3 |
| Plasmodium | ||||||
| Plasmodium falciparum | 12 | 4 | 2 | - | 1 | 11 |
| Plasmodium malariae | 1 | - | - | - | - | - |
| Plasmodium ovale | 1 | - | - | - | - | - |
| Polyomavirus | ||||||
| Polyomavirus BK | 46 | 41 | 40 | 48 | 39 | 48 |
| Polyomavirus JC | 11 | 19 | 9 | 9 | 8 | 4 |
| Polyomavirus untyped | 1 | 1 | - | - | 1 | - |
| Rickettsia | ||||||
| Rickettsia mooseri | - | - | - | 1 | - | - |
| Rickettsia prowazekii | - | - | - | - | - | 2 |
| Rickettsia spotted fever | 1 | - | - | - | - | 1 |
| Rubella virus | ||||||
| Rubella virus | 2 | 1 | 2 | 1 | 3 | 2 |
| Salmonella | ||||||
| Other salmonellas | 74 | 58 | 57 | 53 | 34 | 26 |
| Salmonella agona | - | 5 | 5 | - | - | - |
| Salmonella enteritidis | 96 | 63 | 64 | 34 | 8 | 13 |
| Salmonella infantis | 8 | 7 | 9 | 7 | - | - |
| Salmonella kentucky | 5 | - | - | - | - | - |
| Salmonella newport | - | 6 | - | - | - | - |
| Salmonella sp | 22 | 21 | 49 | 79 | 124 | 172 |
| Salmonella typhi and paratyphi | 10 | 7 | 13 | 9 | 6 | - |
| Salmonella typhimurium | 30 | 35 | 40 | 33 | 6 | 11 |
| Salmonella virchow | 5 | - | - | - | - | - |
| Shigella | ||||||
| Shigella boydii | 2 | - | - | 1 | - | - |
| Shigella dysenteriae | 1 | - | 1 | 2 | 1 | 1 |
| Shigella flexneri | 10 | 11 | 9 | 6 | 5 | 4 |
| Shigella sonnei | 31 | 20 | 22 | 21 | 26 | 23 |
| Shigella sp | 52 | 50 | 46 | 31 | 54 | 75 |
| Streptococcus | ||||||
| Streptococcus group A | 65 | 56 | 69 | 64 | 55 | 65 |
| Streptococcus pneumoniae | 70 | 70 | 65 | 55 | 60 | 71 |
| Vibrio | ||||||
| Vibrio cholerae | - | - | 1 | 1 | 2 | 1 |
Carbapenemase-producing Enterobacterales (CPE)
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/26 | 2023/27 | 2023/28 | 2023/29 | 2023/30 | 2023/31 | |
|---|---|---|---|---|---|---|---|
| Citrobacter | |||||||
| Citrobacter spp | KPC | - | 1 | 2 | 2 | 1 | 1 |
| NDM | 1 | 1 | 1 | - | - | - | |
| OXA48 | 1 | 1 | 2 | 2 | 5 | - | |
| VIM | - | 1 | - | - | - | - | |
| Cronobacter | |||||||
| Cronobacter malonaticus | NDM | 1 | - | - | - | - | - |
| Enterobacter | |||||||
| Enterobacter cloacae complex | IMP | 3 | 4 | - | - | 1 | - |
| KPC | 1 | 2 | 2 | 10 | 9 | 2 | |
| NDM | 6 | 2 | - | 4 | 3 | 1 | |
| OXA48 | 7 | 2 | 3 | 2 | 2 | 1 | |
| VIM | - | 1 | - | 1 | 1 | - | |
| Other | - | 2 | - | 3 | 1 | - | |
| Other enterobacter spp | KPC | 1 | - | 1 | - | - | - |
| NDM | 1 | - | 1 | - | 2 | - | |
| OXA48 | 1 | - | 2 | - | - | - | |
| VIM | - | - | - | - | 1 | - | |
| Escherichia | |||||||
| Escherichia coli | KPC | 2 | 4 | 3 | 8 | 7 | 6 |
| NDM | 10 | 17 | 12 | 20 | 9 | 4 | |
| OXA48 | 13 | 9 | 5 | 13 | 6 | 6 | |
| VIM | 1 | - | - | - | - | - | |
| Other | - | 1 | - | 2 | - | - | |
| Escherichia hermannii | KPC | - | - | - | - | 1 | - |
| Klebsiella | |||||||
| Klebsiella aerogenes | KPC | 1 | - | - | - | 1 | - |
| Klebsiella oxytoca | KPC | 1 | - | 1 | 2 | 3 | 2 |
| NDM | 1 | - | - | - | 1 | 1 | |
| OXA48 | - | - | 1 | 1 | 1 | - | |
| VIM | - | 1 | - | - | - | - | |
| Klebsiella pneumoniae | KPC | 10 | 13 | 5 | 8 | 6 | 4 |
| NDM | 5 | 8 | 8 | 6 | 5 | - | |
| OXA48 | 12 | 5 | 10 | 9 | 9 | 2 | |
| VIM | - | - | 1 | 2 | - | - | |
| Other | 1 | 1 | 1 | 2 | - | - | |
| Klebsiella pneumoniae subsp ozenae | NDM | - | 1 | - | - | - | - |
| Other | - | 1 | - | - | - | - | |
| Klebsiella variicola | NDM | - | - | 1 | - | - | - |
| OXA48 | - | - | - | 1 | - | - | |
| Morganella | |||||||
| Morganella morganii | OXA48 | - | - | - | - | 1 | - |
| Pantoea | |||||||
| Pantoea agglomerans | KPC | - | - | 1 | - | - | - |
| Proteus | |||||||
| Proteus mirabilis | NDM | - | - | - | - | 2 | - |
| OXA48 | - | - | - | - | 1 | - | |
| Raoultella | |||||||
| Raoultella spp | OXA48 | - | - | 1 | - | - | - |
| Serratia | |||||||
| Serratia marcescens/ureilytica | OXA48 | - | - | - | - | 1 | - |
| Other serratia spp | NDM | - | - | - | - | 1 | - |
| OXA48 | - | - | - | - | 1 | - |
Other carbapenemase-producing Gram-negative organisms
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/26 | 2023/27 | 2023/28 | 2023/29 | 2023/30 | 2023/31 | |
|---|---|---|---|---|---|---|---|
| Acinetobacter | |||||||
| Acinetobacter baumannii | IMP | - | - | - | - | - | 1 |
| NDM | - | - | - | - | 1 | - | |
| Acinetobacter pittii | NDM | 1 | - | - | - | - | - |
| Pseudomonas | |||||||
| Pseudomonas aeruginosa | IMP | 1 | - | - | - | - | - |
| NDM | 1 | 1 | - | - | 3 | 1 | |
| VIM | - | 1 | 1 | - | 1 | - | |
| Other | 2 | 1 | 1 | 1 | 1 | - | |
| Pseudomonas nitroreducens | VIM | - | - | - | - | 1 | - |
| Pseudomonas putida group | VIM | - | - | - | - | 1 | - |
| Other | - | - | - | - | 1 | - | |
| Other | |||||||
| Other | - | 1 | - | - | - | - |