Research and analysis
NOIDs causative agents: week 27 (week ending 9 July 2023)
Updated 2 January 2024
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Laboratories in England have a statutory duty to notify the UK Health Security Agency (UKHSA) of the identification of the following causative agents:
- Bacillus anthracis
- Bacillus cereus
- Bordetella pertussis
- Borrelia spp
- Brucella spp
- Burkholderia mallei
- Burkholderia pseudomallei
- Campylobacter spp
- Carbapenemase-producing Gram-negative bacteria
- Chikungunya virus
- Chlamydophila psittaci
- Clostridium botulinum
- Clostridium perfringens
- Clostridium tetani
- Corynebacterium diphtheriae
- Corynebacterium ulcerans
- Coxiella burnetii
- Crimean-Congo haemorrhagic fever virus
- Cryptosporidium spp
- Dengue virus
- Ebola virus
- Entamoeba histolytica
- Escherichia coli O 157
- Francisella tularensis
- Giardia lamblia
- Guanarito virus
- Haemophilus influenzae (invasive)
- Hanta virus
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Hepatitis D
- Hepatitis E
- Influenza virus
- Junin virus
- Kyasanur Forest disease virus
- Lassa virus
- Legionella spp
- Leptospira interrogans
- Listeria monocytogenes
- Machupo virus
- Marburg virus
- Measles virus
- Mpox (monkeypox) virus
- Mumps virus
- Mycobacterium tuberculosis complex
- Neisseria meningitidis
- Omsk haemorrhagic fever virus
- Plasmodium falciparum
- Plasmodium knowlesi
- Plasmodium malariae
- Plasmodium ovale
- Plasmodium vivax
- Polio virus
- Rabies virus
- Rickettsia spp
- Rift Valley fever virus
- Rubella virus
- Sabia virus
- Salmonella spp
- SARS coronavirus
- Shigella spp
- Streptococcus group A (invasive)
- Streptococcus pneumoniae (invasive)
- Varicella zoster virus
- Variola virus
- Vibrio cholerae
- West Nile virus
- Yellow fever virus
- Yersinia pestis
Statutory notifications of causative agents, grouped by root organism
Totals for the current week compared to the previous 5.
| Week notification received | 2023/22 | 2023/23 | 2023/24 | 2023/25 | 2023/26 | 2023/27 |
|---|---|---|---|---|---|---|
| Arboviruses | ||||||
| West Nile virus | 2 | 1 | - | - | 1 | - |
| Bacillus | ||||||
| Bacillus cereus | 17 | 25 | 20 | 24 | 19 | 26 |
| Bordetella | ||||||
| Bordetella pertussis | 4 | 3 | 6 | 22 | 4 | 5 |
| Borrelia | ||||||
| Borrelia burgdorferi | 13 | 24 | 16 | 22 | 27 | 27 |
| Borrelia sp | 2 | 3 | 4 | 4 | 4 | 6 |
| Borrelia tillae | - | 1 | - | - | 2 | 1 |
| Brucella | ||||||
| Brucella sp | 1 | - | - | - | - | - |
| Burkholderia | ||||||
| Burkholderia pseudomallei | 1 | - | - | - | - | - |
| Campylobacter | ||||||
| Campylobacter coli | 27 | 41 | 43 | 70 | 46 | 32 |
| Campylobacter curvus | - | 1 | - | - | - | - |
| Campylobacter fetus | - | - | 1 | 1 | - | - |
| Campylobacter jejuni | 294 | 361 | 401 | 457 | 306 | 262 |
| Campylobacter lari | - | - | 1 | 1 | - | - |
| Campylobacter other named | 1 | 1 | 2 | 3 | 1 | 1 |
| Campylobacter sp | 960 | 1,360 | 1,421 | 1,332 | 1,416 | 1,332 |
| Campylobacter upsaliensis | 1 | - | 1 | 1 | 1 | 1 |
| Campylobacter ureolyticus (bacteroides corrodens) | - | - | 3 | 1 | - | 1 |
| Chikungunya virus | ||||||
| Chikungunya virus | 1 | - | 1 | 1 | 2 | - |
| Clostridium | ||||||
| Clostridium perfringens | 27 | 35 | 27 | 31 | 53 | 39 |
| Coronavirus | ||||||
| Coronavirus | 24 | 23 | 25 | 21 | 8 | 14 |
| Human coronavirus hku1 | - | - | 1 | - | - | - |
| SARS coronavirus | - | 1 | - | - | - | - |
| SARS-CoV-2 antibody indeterminate | 74 | 70 | 116 | 109 | 60 | 88 |
| SARS-CoV-2 antibody void | 2 | 9 | 4 | 4 | 4 | 4 |
| SARS-CoV-2 coronavirus (COVID-19) | 4,705 | 4,298 | 3,215 | 2,504 | 1,873 | 2,180 |
| SARS-CoV-2 coronavirus (COVID-19) indeterminate | 71 | 48 | 96 | 28 | 28 | 34 |
| SARS-CoV-2 IgG antibody negative | 48 | 46 | 87 | 75 | 50 | 47 |
| SARS-CoV-2 IgG antibody positive | 120 | 173 | 376 | 346 | 127 | 128 |
| SARS-CoV-2 total antibody negative | 38 | 62 | 58 | 42 | 24 | 44 |
| SARS-CoV-2 total antibody positive | 118 | 136 | 158 | 125 | 126 | 117 |
| Corynebacterium | ||||||
| Corynebacterium diphtheriae | 1 | 7 | - | 3 | - | 4 |
| Corynebacterium ulcerans | 1 | - | 2 | - | - | 2 |
| Coxiella | ||||||
| Coxiella burnetii | - | 1 | - | - | - | - |
| Cryptosporidium | ||||||
| Cryptosporidium hominis | 5 | 6 | 8 | 5 | 7 | 4 |
| Cryptosporidium meleagridis | - | 1 | 2 | 1 | - | - |
| Cryptosporidium parvum | 46 | 45 | 42 | 42 | 23 | 4 |
| Cryptosporidium sp | 20 | 26 | 25 | 24 | 21 | 56 |
| Cryptosporidium ubiquitum | 1 | - | 1 | - | - | - |
| Entamoeba | ||||||
| Entamoeba histolytica | 1 | 1 | 1 | 1 | 1 | 2 |
| Escherichia | ||||||
| Escherichia coli O 157 | 17 | 17 | 11 | 20 | 17 | 15 |
| Flaviviruses | ||||||
| Dengue virus | 4 | 4 | 2 | 1 | 3 | 2 |
| Haemophilus | ||||||
| Haemophilus influenzae | 74 | 64 | 61 | 62 | 72 | 64 |
| Hepatitis viruses | ||||||
| Hepatitis A | 8 | 20 | 14 | 16 | 9 | 12 |
| Hepatitis B | 259 | 309 | 305 | 298 | 310 | 211 |
| Hepatitis C | 332 | 407 | 424 | 443 | 412 | 410 |
| Hepatitis D | 3 | 4 | 5 | 8 | 7 | 5 |
| Hepatitis E | 20 | 29 | 39 | 28 | 47 | 35 |
| Influenza virus | ||||||
| Influenza A | 50 | 41 | 48 | 60 | 25 | 56 |
| Influenza B | 26 | 34 | 28 | 26 | 13 | 15 |
| Influenza indeterminate | 1 | 5 | - | 1 | - | - |
| Influenza ungrouped | 1 | 2 | 3 | 2 | 1 | - |
| Legionella | ||||||
| Legionella longbeachae | - | 1 | - | - | - | 1 |
| Legionella pneumophila | 2 | 8 | 5 | 10 | 10 | 5 |
| Legionella sp | 1 | 4 | 4 | 2 | 3 | 2 |
| Listeria | ||||||
| Listeria monocytogenes | 6 | 3 | 7 | 16 | 5 | 8 |
| Mycobacterium | ||||||
| Mycobacterium tuberculosis | 106 | 104 | 108 | 100 | 78 | 81 |
| Neisseria | ||||||
| Neisseria meningitidis | 8 | 15 | 25 | 19 | 12 | 20 |
| Orthopoxvirus | ||||||
| Mpox virus | 3 | 4 | 1 | 4 | 1 | 3 |
| Paramyxoviruses | ||||||
| Measles virus | 2 | 5 | 2 | 6 | 7 | 3 |
| Mumps virus | 2 | - | 13 | 2 | 2 | 6 |
| Plasmodium | ||||||
| Plasmodium falciparum | 2 | - | 18 | 1 | 12 | 4 |
| Plasmodium malariae | - | - | - | - | 1 | - |
| Plasmodium ovale | - | - | 1 | - | 1 | - |
| Plasmodium vivax | - | - | 1 | - | - | - |
| Polyomavirus | ||||||
| Polyomavirus BK | 34 | 38 | 38 | 86 | 46 | 41 |
| Polyomavirus JC | 8 | 12 | 12 | 13 | 11 | 19 |
| Polyomavirus untyped | - | 1 | - | 2 | 1 | 1 |
| Rickettsia | ||||||
| Rickettsia spotted fever | - | 2 | - | - | 1 | - |
| Rubella virus | ||||||
| Rubella virus | 5 | 4 | 2 | 5 | 2 | 1 |
| Salmonella | ||||||
| Other salmonellas | 63 | 61 | 72 | 64 | 53 | 16 |
| Salmonella agona | - | - | 8 | - | - | - |
| Salmonella chester | - | 6 | - | 6 | - | - |
| Salmonella enteritidis | 66 | 65 | 93 | 83 | 56 | 21 |
| Salmonella infantis | - | - | 11 | - | 6 | - |
| Salmonella newport | - | - | 5 | - | - | - |
| Salmonella panama | - | - | 5 | - | - | - |
| Salmonella sp | 9 | 9 | 19 | 26 | 105 | 138 |
| Salmonella stanley | 5 | 5 | - | - | - | - |
| Salmonella typhi and paratyphi | 14 | 17 | 6 | 9 | 10 | 5 |
| Salmonella typhimurium | 35 | 31 | 24 | 33 | 18 | 8 |
| Salmonella enterica | 6 | - | - | - | - | - |
| Shigella | ||||||
| Shigella boydii | - | 2 | - | - | 2 | - |
| Shigella dysenteriae | 1 | - | 2 | 1 | 1 | - |
| Shigella flexneri | 17 | 13 | 18 | 6 | 8 | 9 |
| Shigella sonnei | 11 | 35 | 28 | 24 | 31 | 13 |
| Shigella sp | 42 | 40 | 66 | 49 | 55 | 52 |
| Streptococcus | ||||||
| Streptococcus group A | 67 | 92 | 82 | 91 | 64 | 55 |
| Streptococcus pneumoniae | 113 | 104 | 91 | 106 | 68 | 67 |
| Vibrio | ||||||
| Vibrio cholerae | - | 1 | 3 | - | - | - |
Carbapenemase-producing Enterobacterales (CPE)
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/22 | 2023/23 | 2023/24 | 2023/25 | 2023/26 | 2023/27 | |
|---|---|---|---|---|---|---|---|
| Citrobacter | |||||||
| Citrobacter spp | KPC | 1 | 1 | - | - | - | - |
| NDM | 1 | 4 | - | 1 | 1 | - | |
| OXA48 | 1 | 5 | 3 | 1 | 1 | - | |
| Other | - | 1 | - | - | - | - | |
| Cronobacter | |||||||
| Cronobacter malonaticus | NDM | - | - | - | - | 1 | - |
| Enterobacter | |||||||
| Enterobacter cloacae complex | IMP | 3 | - | - | 1 | 3 | - |
| KPC | 5 | 2 | 6 | 1 | 1 | 2 | |
| NDM | 7 | 9 | 4 | 7 | 6 | - | |
| OXA48 | 1 | - | 3 | 2 | 6 | - | |
| Other | - | 1 | - | 1 | - | 1 | |
| Other enterobacter spp | IMP | - | 2 | 1 | - | - | - |
| KPC | - | - | - | - | 1 | - | |
| NDM | - | 1 | - | 1 | 1 | - | |
| OXA48 | - | - | - | - | 1 | - | |
| VIM | - | 1 | - | 1 | - | - | |
| Escherichia | |||||||
| Escherichia coli | IMP | - | - | 3 | - | - | - |
| KPC | 3 | 5 | 6 | 7 | 2 | 4 | |
| NDM | 10 | 13 | 9 | 13 | 9 | 6 | |
| OXA48 | 15 | 13 | 16 | 11 | 9 | 2 | |
| VIM | - | 1 | 1 | 1 | 1 | - | |
| Other | 2 | 1 | - | 1 | - | - | |
| Klebsiella | |||||||
| Klebsiella aerogenes | KPC | - | - | - | - | 1 | - |
| NDM | 1 | - | - | - | - | - | |
| OXA48 | 1 | - | - | - | - | - | |
| Other | - | - | 1 | - | - | - | |
| Klebsiella oxytoca | KPC | 2 | 1 | 1 | - | 1 | - |
| NDM | 1 | - | - | - | 1 | - | |
| OXA48 | 1 | 1 | - | 1 | - | - | |
| Other | - | - | - | 1 | - | - | |
| Klebsiella pneumoniae | IMP | - | 1 | 1 | - | - | - |
| KPC | 7 | 6 | 11 | 8 | 10 | 9 | |
| NDM | 4 | 11 | 2 | 8 | 5 | 3 | |
| OXA48 | 7 | 14 | 3 | 7 | 9 | 1 | |
| VIM | - | 1 | 1 | 1 | - | - | |
| Other | - | 1 | 1 | 1 | 1 | - | |
| Klebsiella serogenes | NDM | - | - | - | 1 | - | - |
| OXA48 | - | - | - | 1 | - | - | |
| VIM | - | - | - | 1 | - | - | |
| Other | - | - | - | 1 | - | - | |
| Other klebsiella spp | OXA48 | - | - | - | 1 | - | - |
| VIM | - | 1 | - | - | - | - | |
| Morganella | |||||||
| Morganella morganii | OXA48 | - | 1 | - | - | - | - |
| Pluralibacter | |||||||
| Pluralibacter gergoviae | Other | - | - | - | 1 | - | - |
| Proteus | |||||||
| Proteus mirabilis | NDM | - | 1 | - | - | - | - |
| OXA48 | - | 1 | - | - | - | - | |
| Other proteus spp | KPC | - | - | 1 | - | - | - |
| Serratia | |||||||
| Serratia marcescens/ureilytica | NDM | 1 | - | - | - | - | - |
Other carbapenemase-producing Gram-negative organisms
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
| Week notification received | 2023/22 | 2023/23 | 2023/24 | 2023/25 | 2023/26 | 2023/27 | |
|---|---|---|---|---|---|---|---|
| Acinetobacter | |||||||
| Acinetobacter baumannii | NDM | 1 | 1 | - | - | - | - |
| Other | 1 | - | - | - | - | - | |
| Acinetobacter calcoaceticus/baumannii complex | IMP | - | - | - | 1 | - | - |
| NDM | 1 | - | - | - | - | - | |
| Other | 1 | - | - | - | - | - | |
| Acinetobacter pittii | NDM | - | - | - | - | 1 | - |
| Other acinetobacter spp | NDM | - | - | - | 1 | - | - |
| Pseudomonas | |||||||
| Pseudomonas aeruginosa | NDM | - | 1 | - | - | 1 | 1 |
| VIM | - | - | - | 1 | - | - | |
| Other | 1 | 3 | 3 | 1 | 2 | 1 | |
| Other pseudomonas spp | NDM | 1 | - | - | - | - | - |
| Other | |||||||
| KPC | 1 | - | 1 | - | - | - | |
| OXA48 | 1 | - | - | - | - | - | |
| Other | - | 1 | - | - | - | - |
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.