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Non-tech. summaries 2014: projects on other human disorders

Projects granted during 2014 that have a primary purpose of translational and applied research: other human disorders.

From:
Home Office
Published
14 April 2016

Documents

Non-technical summaries: projects granted in 2014, volume 3

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2014 that have a primary purpose of translational and applied research - other human disorders, including:

  • respiratory disorders
  • gastrointestinal disorders including liver
  • immune disorders
  • urogenital/reproductive disorders

The following projects were granted:

  • gene transfer to small animals (gene therapy, genetic disease)
  • development of assays to quantify gluten content in gluten-free foods (coeliac disease, gluten, monoclonal antibodies)
  • zebrafish as a model of inherited renal disease (cystic kidney, cilial, treatment, pronephros)
  • neurodevelopmental disorders: causes and treatment (autism, schizophrenia, genes, environmental risk factors, phenotyping)
  • development of diagnostics and therapeutics for pancreatitis (pancreatitis; acute; chronic; diagnostics; therapeutics)
  • models of airway inflammation (respiratory, inflammation, in-vivo, infection, PK/PD)
  • novel therapies to treat autoimmune diseases (diabetes, multiple sclerosis, EAE, lupus, psoriasis)
  • immunology studies to support drug discovery (immunology, inflammation)
  • genetic models to study inflammatory diseases (inflammation, arthritis, infection, PAR-2, MKP-2)
  • interventions against chlamydia (chlamydia, macaque, vaccine, efficacy, immunogenicity)
  • mechanisms and treatments of renal transplant-related injury in mouse models (ischemia/reperfusion (I/R) injury, immunosuppressant-cyclosporine A (CsA), erythropoietin (EPO) derived new cyclic helix B surface peptide (CHBP), caspase-3 small interfering RNA (siRNA) and genetic modified mice)
  • finding treatments for chronic kidney disease (kidney, fibrosis, CKD)
Published 14 April 2016

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