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Non-tech. summaries 2015: projects on nervous system and mental disorders

Projects granted during 2015 that have a primary purpose of translational and applied research: human nervous system and mental disorders.



This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of translational and applied research: human nervous system and mental disorders.

The following projects were granted:

  • white matter and glial function and pathology (glia, astrocyte, oligodendrocyte, white matter, nervous system)
  • improving translation in Parkinson’s disease (cell transplantation, side effects, disease models)
  • brain mechanisms of cognition and behaviour (brain, cognition, behaviour, rats)
  • brain injury and repair (brain, stroke, optic nerve, plasticity, neuronal growth)
  • disruption of biological rhythms and stroke (stroke, hyperglycemia, hypertension, obesity, circadian rhythm)
  • neuroprotective effects of novel incretin analogues in models of Parkinson’s disease (Parkinson’s disease, rigor, tremor, drug development, dopamine)
  • studies of transgenic rodents that express human amyloid protein (Transgenic, rodents, human, amyloid, protein)
  • bioelectronic medicines (electrophysiology, implantable devices)
  • DNA strand breaks, DNA damage responses, and disease (DNA damage, neurodegeneration, cancer)
  • understanding rare intellectual disability syndromes (cerebellar atrophy, ataxia, bone mineralisation, hyperostosis, intellectual disability)
  • drug development in Dravet syndrome (epilepsy, Dravet syndrome, seizures, drug development)
  • the development of vaccine against specific domains of NMDAR to allow pre-treatment of patients at high risk of stroke (stroke, vaccine)
  • therapies in Parkinson’s and Huntington’s disease (neurodegenerative disease model, treatment, behaviour)
  • role of the environment in drug abuse development (drug abuse, rat, environment, context)
  • preclinical screening in drug discovery (imaging, drug discovery, disease models)
  • physiology and pathophysiology of motor circuitry (zebrafish, electrophysiology, motor network)
  • sheep as a large animal models in health and disease (Huntington disease, sheep, behaviour, electrophysiology)
  • understanding locomotor control mechanisms (locomotor circuit, development, neuroregeneration, electrophysiology)
  • mechanisms underlying Rett syndrome and other autism spectrum disorders (sensory processing, Rett syndrome, EEG, neurons, autism)
  • regulation of body glucose and energy levels by the brain (diabetes, obesity, glucose, energy, brain)
  • developing in vivo Raman spectroscopy in mice (Raman spectroscopy, neuromuscular disease)
  • mutations in matrix proteins and disease (stroke, vascular disease, collagen)
  • molecular mechanisms underlying neurogenesis and neurodegeneration (nervous system, neurodegeneration, mouse models)
  • new medicines for amyloid and C-reactive protein (amyloidosis, serum amyloid P component, monoclonal antibody, immunotherapy, drug development)
  • brain protection for birth asphyxia (birth asphyxia, brain protection, newborn, therapeutic hypothermia)
  • protein function in genetically altered and stroke mice (brain, stroke, brain compounds, receptors)
  • therapeutic strategies in developmental disorders (neurology, autism, intellectual disability, Rett syndrome)
  • sensory feedback in artificial limbs (sensory, artificial limbs, stimulation, peripheral nerve)
  • repairing the damaged spinal cord (spinal cord injury, axon regeneration, neuroprotection, scarring, cavitation)