Research and analysis

Doxycycline: serious or severe adverse effects

Evidence from systematic reviews of serious or severe adverse effects experienced by people taking doxycycline.

• From: UK Health Security Agency
• Published: 17 July 2025

Documents

Serious or severe adverse effects experienced by people taking doxycycline: a rapid review of systematic reviews

Ref: GOV-18490, Published July 2025

PDF, 551 KB, 36 pages

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Details

This review summarised evidence from recent systematic reviews on serious or severe adverse effects of doxycycline taken for up to 30 days, focusing on short to medium-term use (search from January 2021 up to 12 August 2024 to follow on from a recent systematic review).

This review included 3 systematic reviews comparing doxycycline to other antibiotics or placebo for the treatment of medical conditions or as a preventive measure against infections, which in total included evidence from 3,372 participants including both children and adults and both men and women.

Published 17 July 2025