Research and analysis

Deriving acceptable concentrations for endocrine disrupting chemicals using aquatic toxicity data

Tests approaches to derive predicted no effect concentrations for endocrine disrupting chemicals.

From:
Environment Agency
Published
29 January 2026

Documents

Deriving acceptable concentrations for endocrine disrupting chemicals using aquatic toxicity data: summary

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Deriving acceptable concentrations for endocrine disrupting chemicals using aquatic toxicity data: report

PDF, 3 MB, 257 pages

Details

There is no current regulatory guidance on determining acceptable concentrations for environmental endocrine disrupting chemicals (EDCs) under the UK Registration, Evaluation, Authorisation and restriction of CHemicals (UK REACH) regulation.

This project aimed to close this gap by testing approaches to derive predicted no effect concentrations (PNECs) using aquatic ecotoxicity datasets, and ensuring these thresholds are protective of mechanistic effects. This is relevant to both the risk assessment and risk management of EDCs, including applications for authorisation under UK REACH.

Updates to this page

Published 29 January 2026

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