The work, which will consist of urgent carriageway repairs to a 70m patch in lane two of the exit slip road of the northbound A1(M) at junction 6.
The slip road, lanes one and two will be closed from 10pm until 5am the following morning (Friday).
During the closure traffic will be diverted to continue on the A1(M) and leave at junction 7 where they will turn back onto the southbound carriageway to head back towards junction 6.
Motorists affected by this work are advised to plan ahead and allow extra time for travel.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.