Work will take place between 8pm and 5am to maintain the bridge and replace worn-out components.
During the work the A12 will be closed in both directions at the bridge and a diversion between the Pasteur Road roundabout and the Vauxhall roundabout (Acle New Road) will be clearly signposted via the A1243, B1141 and A149.
Motorists affected by this work are advised to plan ahead and allow extra time for travel.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.