Contractors for Highways England will be resurfacing the eastbound exit slip road at Headley Bar and the westbound carriageway between Tadcaster Ings and Headley Bar.
All work will be completed overnight between 8pm and 6am with clearly signed diversions in place.
Highways England project manager Adeeb Saeed said:
This work was postponed from January due to the severe flooding which affected Tadcaster. We have been working closely with North Yorkshire County Council and have agreed to begin the resurfacing work along the A64.
It is essential maintenance and we have carefully looked at the diversion routes to ensure the people of Tadcaster can still get from one side to the other.
We will carry this work out overnight when traffic levels are at their lowest to keep disruption to a minimum.
During this work the eastbound exit slip road will be closed with traffic being diverted via Bilbrough Top to return to Tadcaster on the westbound carriageway. This work is expected to take around one week to complete.
The eastbound carriageway will also be closed during this time between Bramham A1(M) junction and Tadcaster Ings (A162) for two nights which is currently planned for Friday 19 and Saturday 20 February. During this time traffic will be diverted along the A59 and A1237 to rejoin the A64.
Once this work has been completed work will start on resurfacing the westbound carriageway. This is expected to take around two weeks and traffic will be diverted off the A64 at Askham Bar on to the A1237 and A59. People wanting to access Tadcaster on the west side will be able to travel along the A64 to the A162 and people on the east will be able to leave on the A659.
Work is currently planned to start on Monday 29 February until the end of March for footway improvements. This work between Bramham and Headley Bar will require lane closures.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.