The work, which will involve renewing a series of bridge joints, will take place on the northbound A1(M) at junction 6.
The road will be closed from 10pm until 5am from Monday (21 September) for 8 nights.
During the closure traffic will be diverted off the A1(M) at junction 6, onto the A1000 to Clock roundabout and re-join the A1(M) northbound at junction 6.
Highways England project manager Mark Saunders said:
We will be working on 6 bridge joints in total and will need a total closure in order for the work to be carried out safely.
We’re advising motorists affected by this work to plan ahead and allow extra time for travel.
Members of the public should contact the Highways England customer contact centre on 0300 123 5000.
Journalists should contact the Highways England press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.
Published 15 September 2015