Work to replace the joints on Bescot Viaduct, which carries the M6 over the River Tame near Walsall, starts on Monday 24 November for six weeks.
The southbound carriageway of the M6 will be closed between junction 10 and junction 8 each night from 10pm to 6am, as will the entry slip roads at junctions 10 and 9.
Highways Agency project manager Jessica Kenny said:
Bridge joints contract and expand with the weather or weight of traffic and make sure the bridge does not deteriorate. Renewing them will ensure the continued safety of the viaduct.
To carry it out safely and efficiently we need to close the motorway. While the motorway is closed however, we will take the opportunity to resurface all three lanes and the hard shoulder. This will avoid the need for further disruption to road users in the future.
Southbound traffic and traffic intending to join the M6 southbound at junction 10 will be diverted via the A454, the A4148 Walsall Ring Road and the A34 to join the M6 at junction 7.
Traffic intending to join the M6 southbound at junction 9 will be diverted along the A461 to the A4148 Walsall Ring Road where it will follow the same diversion as above.
Members of the public should contact the Highways Agency Information Line on 0300 123 5000.
Journalists should contact the Highways Agency press office on 0844 693 1448 and use the menu to speak to the most appropriate press officer.